Attributes | Values |
---|
rdf:type
| |
Description
| - Mitocans are drugs selectively killing cancer cells by destabilizing mitochondria and generate reactive oxygen species (ROS). However, the molecular events by which ROS production leads to apoptosis has not been clearly defined. In this study with the mitocan alpha-tocopheryl succinate (alpha-TOS) the role of the Bcl-2 family proteins in the mechanism of malignant cell apoptosis has been determined. Exposure of several different cancer cell lines to alpha-TOS caused a profound conformational change in the pro-apoptotic protein, Bak, involving oligomerization in all cell types tested. Bak forms high molecular weight complexes in the mitochondria upon alfa-TOS treatment. We conclude that the major events induced by alpha-TOS in cancer cells downstream of ROS production leading to mitochondrial apoptosis involve the Noxa-Bak axis. It is proposed that this represents a common mechanism for mitochondrial destabilization activated by a variety of mitocans that induce accumulation of ROS.
- Mitocans are drugs selectively killing cancer cells by destabilizing mitochondria and generate reactive oxygen species (ROS). However, the molecular events by which ROS production leads to apoptosis has not been clearly defined. In this study with the mitocan alpha-tocopheryl succinate (alpha-TOS) the role of the Bcl-2 family proteins in the mechanism of malignant cell apoptosis has been determined. Exposure of several different cancer cell lines to alpha-TOS caused a profound conformational change in the pro-apoptotic protein, Bak, involving oligomerization in all cell types tested. Bak forms high molecular weight complexes in the mitochondria upon alfa-TOS treatment. We conclude that the major events induced by alpha-TOS in cancer cells downstream of ROS production leading to mitochondrial apoptosis involve the Noxa-Bak axis. It is proposed that this represents a common mechanism for mitochondrial destabilization activated by a variety of mitocans that induce accumulation of ROS. (en)
|
Title
| - alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels
- alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels (en)
|
skos:prefLabel
| - alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels
- alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels (en)
|
skos:notation
| - RIV/00027162:_____/10:#0000624!RIV11-GA0-00027162
|
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| - P(GP204/09/P632), P(IAA500520602), P(IAA500520702), P(KAN200520703), Z(AV0Z50520701), Z(MZE0002716202)
|
http://linked.open...iv/cisloPeriodika
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/00027162:_____/10:#0000624
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| - Vitamin E succinate; Apoptosis; Bak; Noxa; Mitochondria; Permeabilization (en)
|
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...odStatuVydavatele
| |
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...i/riv/nazevZdroje
| |
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...vavai/riv/projekt
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...v/svazekPeriodika
| |
http://linked.open...iv/tvurceVysledku
| - Ralph, S. J.
- Dong, L.
- Procházka, Lubomír
- Turánek, Jaroslav
- Freeman, R.
- Neužil, J.
- Valis, K.
|
http://linked.open...ain/vavai/riv/wos
| |
http://linked.open...n/vavai/riv/zamer
| |
issn
| |
number of pages
| |
is http://linked.open...avai/riv/vysledek
of | |