About: Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It is well known that oligomeric/aggregated amyloid ß peptides are a key player in the pathogenesis of Alzheimer disease and that different nanoparticles influence oligomerization/aggregation processes in experiments in vitro. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24 hours. Our results are as follows: i) fluorescence of samples without nanoparticles was significantly higher in both older groups (old controls and people with Alzheimer disease) than in those of younger (young controls and people with multiple sclerosis), ii) nanoparticles did not markedly influence a fluorescence intensity in young people but eliminated it in both old groups; nevertheless, the effects of nanoparticles were significantly lower in patients with Alzheimer disease then in the age-matched controls, and finally iii) significant positive co It is well known that oligomeric/aggregated amyloid ß peptides are a key player in the pathogenesis of Alzheimer disease and that different nanoparticles influence oligomerization/aggregation processes in experiments in vitro. In the study, Thioflavin T based fluorescence was evaluated on cerebrospinal fluid samples from people with Alzheimer disease/multiple sclerosis and corresponding age-related controls using magnetite nanoparticles incubated for 24 hours. Our results are as follows: i) fluorescence of samples without nanoparticles was significantly higher in both older groups (old controls and people with Alzheimer disease) than in those of younger (young controls and people with multiple sclerosis), ii) nanoparticles did not markedly influence a fluorescence intensity in young people but eliminated it in both old groups; nevertheless, the effects of nanoparticles were significantly lower in patients with Alzheimer disease then in the age-matched controls, and finally iii) significant positive co (en)
Title	Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease (en)
skos:prefLabel	Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease (en)
skos:notation	RIV/00023752:_____/10:00001075!RIV11-GA0-00023752
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(GA305/09/0457), P(NS10369)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Řípová, Daniela Bartoš, Aleš Říčný, Jan Krištofiková, Zdena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Národní ústav duševního zdraví
http://linked.open...dnocenehoVysledku	248071
http://linked.open...ai/riv/idVysledku	RIV/00023752:_____/10:00001075
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	magnetite nanoparticles; aggregation; Alzheimer disease (en)
http://linked.open.../riv/klicoveSlovo	Alzheimer disease aggregation magnetite nanoparticles
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[0BC55C82EB9E]
http://linked.open...i/riv/nazevZdroje	Molecular Biosystems
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Evaluation of the binding between cerebrosterol and amyloid beta peptide 1-40 Use of neurocytoskeletal proteins and antibodies against them for diagnosis of Alzheimer´s disease
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	6
http://linked.open...iv/tvurceVysledku	Bartoš, Aleš Čechová, Linda Řípová, Daniela Říčný, Jan Klaschka, Jan Krištofiková, Zdena Gažová, Zuzana Antošová, Andrea
http://linked.open...ain/vavai/riv/wos	000282765000013
issn	1742-206X
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease

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