About: Evaluation of the binding between cerebrosterol and amyloid beta peptide 1-40

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=GA305/09/0457
Description	Although causes of Alzheimer disease are not known yet in a detail, it is suggested that amyloid beta peptides play a key role in the pathogenesis of disease. Toxicity of peptides is probably closely connected with their ability to ologomerize or to form complexes with different endogenous substances. A great attention is now focused on the research od drugs that via binding to amyloid beta peptides can eliminated their toxic effects and that could be applied in Alzheimer disease therapy. E.g., the stereospecific binding to naturally occurring 22R-hydroxy-cholesterol decreases peptide toxicity and enantiomer 22S-hydroxycholesterol is not effective. Naturally occurring and brain-originating 24S-hydroxycholesterol (cerebrosterol) is a very efficient inhibitor of amyloid beta peptide secretion in experiments in vitro. Our previous work indicated the decreased actions of nonaggregated and aggregated peptides when racemic 24-hydroxycholesterol was added and data suggested a formation of the complex as probable. However, interaction mechanisms are not known yet in a detail. (en) Cíle projektu jsou následující: 1) otestovat účinky L- a D-enantiomerů fragmentu amyloidu beta 1-40 a 24S- a 24R-hydroxycholesterolu, 2) zjistit, zda je interakce mezi přirozeně se vyskytujícím L-fragmentem 1-40 a cerebrosterolem stereospecifická a 3)pokusit se vytvořit počítačový model komplexu.
Title	Evaluation of the binding between cerebrosterol and amyloid beta peptide 1-40 (en) Testování vazby mezi cerebrosterolem a peptidem amyloidu beta 1-40
skos:notation	GA305/09/0457
http://linked.open...avai/cep/aktivita	Standard projects
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/GA305%2F09%2F0457/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/GA305%2F09%2F0457/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-03-02 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	91497430
http://linked.open...ai/cep/hlavniObor	CE - Biochemie
http://linked.open...hodnoceniProjektu	U - Uspěl podle zadání, tj. byly splněny cíle a jeho předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory
http://linked.open...vai/cep/kategorie	ZV - Základní výzkum
http://linked.open.../cep/klicovaSlova	cerebrosterol; peptidy amyloidu beta; komplex; stereospecifická vazba; Alzheimerova demence (en)
http://linked.open...ep/partnetrHlavni	Psychiatrické centrum Praha
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	2 (xsd:int)
http://linked.open.../pocetVysledkuRIV	6 (xsd:int)
http://linked.open...enychVysledkuVRIV	6 (xsd:int)
http://linked.open...lneniVMinulemRoce	2011-04-16 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/305%2F09%2F0457
http://linked.open...iciPoslednihoRoku	2011
http://linked.open...atUdajeProjZameru	2012
http://linked.open.../vavai/cep/soutez	SGA02009GA-ST
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2011-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	ED - Fyziologie FH - Neurologie, neurochirurgie, neurovědy
http://linked.open...ep/zahajeniReseni	2009-01-01 (xsd:date)
http://linked.open...jektu+dodavatelem	The project gone according to plan both in terms of expertise and in terms of disbursement of funds. (en) Řešení projektu proběhlo podle plánu jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
http://linked.open...tniCyklusProjektu	ZBKU
http://linked.open.../cep/klicoveSlovo	komplex peptidy amyloidu beta stereospecifická vazba cerebrosterol
is http://linked.open...vavai/riv/projekt of	Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer´s disease Stereospecific interactions of amyloid ß peptides Interactions of Amyloid beta Peptide 1 - 40 and Cerebrosterol Instability of cerebrospinal fluid after delayed storage and repeated freezing: a holistic study by drop coating deposition Raman spectroscopy How ionic strength affects the conformational behavior of human and rat beta amyloids - a computational study Differences in conformational behavior of amyloid beta in solvent with different ionic strength
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