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  • The amygdala plays an important role in the regulation of emotions and has been implicated in the pathophysiology of mood disorders. Studies of amygdala volumes in mood disorders have been conflicting, with findings of increased, decreased and unchanged amygdala volumes in patients relative to controls. We present the largest meta-analysis of amygdala volumes in mood disorders and the first one to investigate modifying effects of clinical, demographic and methodological variables. METHODS: We reviewed 40 magnetic resonance imaging studies investigating amygdala volumes in patients with unipolar or bipolar disorders. For meta-analysis we used standardized differences in means (SDM) and random effect models. In the search for sources of heterogeneity, we subdivided the studies based on diagnosis, setting, age, medication status, sex, duration of illness, slice thickness, interrater reliability of tracing and anatomical definitions used. RESULTS: The volumes of the left and right amygdala in bipolar (N=
  • The amygdala plays an important role in the regulation of emotions and has been implicated in the pathophysiology of mood disorders. Studies of amygdala volumes in mood disorders have been conflicting, with findings of increased, decreased and unchanged amygdala volumes in patients relative to controls. We present the largest meta-analysis of amygdala volumes in mood disorders and the first one to investigate modifying effects of clinical, demographic and methodological variables. METHODS: We reviewed 40 magnetic resonance imaging studies investigating amygdala volumes in patients with unipolar or bipolar disorders. For meta-analysis we used standardized differences in means (SDM) and random effect models. In the search for sources of heterogeneity, we subdivided the studies based on diagnosis, setting, age, medication status, sex, duration of illness, slice thickness, interrater reliability of tracing and anatomical definitions used. RESULTS: The volumes of the left and right amygdala in bipolar (N= (en)
Title
  • Amygdala volumes in mood disorders - meta-analysis of magnetic resonance volumetry studies
  • Amygdala volumes in mood disorders - meta-analysis of magnetic resonance volumetry studies (en)
skos:prefLabel
  • Amygdala volumes in mood disorders - meta-analysis of magnetic resonance volumetry studies
  • Amygdala volumes in mood disorders - meta-analysis of magnetic resonance volumetry studies (en)
skos:notation
  • RIV/00023752:_____/09:00000950!RIV10-MZ0-00023752
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(NR8786), V
http://linked.open...iv/cisloPeriodika
  • 3
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 302668
http://linked.open...ai/riv/idVysledku
  • RIV/00023752:_____/09:00000950
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • bipolar disorder; unipolar depression; meta-analysis; amygdala (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [E10B27987D2C]
http://linked.open...i/riv/nazevZdroje
  • Journal of Affective Disorders
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 115
http://linked.open...iv/tvurceVysledku
  • Hájek, Tomáš
  • Höschl, Cyril
  • Kopeček, Miloslav
  • Kožený, Jiří
  • Alda, M.
  • Gunde, E.
http://linked.open...ain/vavai/riv/wos
  • 000266347600014
issn
  • 0165-0327
number of pages
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