About: The effect of a histone deacetylase inhibitor : valproic acid : on nucleoli in human leukaemic myeloblasts     Goto   Sponge   NotDistinct   Permalink

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  • Human myeloblasts in short-term bone marrow cultures from patients suffering from acute myeloid leukemia were treated by a histone deacetylase inhibitor – valproic acid. That histone deacetylase inhibitor reduced the nucleolar size and nucleolar RNA transcription activity. In addition, it induced the apoptotic process and formation of apoptotic bodies. The nucleolar size and transformation of active to resting or inactive nucleoli represented convenient markers of the sensitivity and alteration of leukemic myeloblasts produced by the tested histone deacetylase inhibitor.
  • Human myeloblasts in short-term bone marrow cultures from patients suffering from acute myeloid leukemia were treated by a histone deacetylase inhibitor – valproic acid. That histone deacetylase inhibitor reduced the nucleolar size and nucleolar RNA transcription activity. In addition, it induced the apoptotic process and formation of apoptotic bodies. The nucleolar size and transformation of active to resting or inactive nucleoli represented convenient markers of the sensitivity and alteration of leukemic myeloblasts produced by the tested histone deacetylase inhibitor. (en)
Title
  • The effect of a histone deacetylase inhibitor : valproic acid : on nucleoli in human leukaemic myeloblasts
  • The effect of a histone deacetylase inhibitor : valproic acid : on nucleoli in human leukaemic myeloblasts (en)
skos:prefLabel
  • The effect of a histone deacetylase inhibitor : valproic acid : on nucleoli in human leukaemic myeloblasts
  • The effect of a histone deacetylase inhibitor : valproic acid : on nucleoli in human leukaemic myeloblasts (en)
skos:notation
  • RIV/00023736:_____/10:00008777!RIV11-MZ0-00023736
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, Z(MSM0021620813), Z(MZ0UHKT2005)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 255858
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/10:00008777
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • nucleoli; histone deacetylase inhibitors; leukemic myeloblasts (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [D0017E5590EA]
http://linked.open...i/riv/nazevZdroje
  • Folia Biologica
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 56
http://linked.open...iv/tvurceVysledku
  • Smetana, Karel
  • Zápotocký, M.
http://linked.open...ain/vavai/riv/wos
  • 000284254900002
http://linked.open...n/vavai/riv/zamer
issn
  • 0015-5500
number of pages
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