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Description
| - V průběhu aterogenézy dochází k migraci leukocytů do subendoteliálních vaskulárních prostorů. Endoteliální a leukocytární adhezivní molekuly mají významnou roli v patogenezi aterogenézy. Pracovní hypotézou bylo, že u pacientů s hypercholesterolemií dochází k významnější alteraci leukocytárních adhezivních molekul. Bylo provedeno vyšetření 27 normálů a 29 pacientů s cholesterolemií před a 12 týdnů po terapii atorvastatinem (20 mg a den). Exprese leukocytárních integrinů CD11a, CD11b,CD18,CD49b a L-selektinu byla stanovena průtokovou cytometrií, stanovení sérových hladin ICAM-1,E-selektinu a von Willebrandova faktoru bylo provedeno metodou ELISA. (cs)
- Atherogenesis involves the migration of leukocytes into vascular subendothelial space, a process mediated by endothelial and leukocyte cell adhesion molecules. Endothelial molecules are assessed indirectly via serum levels, but leukocyte molecules can be assessed directly. We have therefore hypothesized that leukocyte adhesion molecules are altered to a greater degree in hypercholesterolemia than serum endothelial adhesion molecules. We examined 29 subjects with hypercholesterolemia and 27 controls at baseline and after 12 weeks of atorvastatin treatment (20 mg/day). Expression of leukocyte integrins CD11a,CD11b, CD18, and CD49d and of L-selectin was measured by flow cytometry. Serum ICAM-1, E-selectin and von Willebrand factor were measured by ELISA.
- Atherogenesis involves the migration of leukocytes into vascular subendothelial space, a process mediated by endothelial and leukocyte cell adhesion molecules. Endothelial molecules are assessed indirectly via serum levels, but leukocyte molecules can be assessed directly. We have therefore hypothesized that leukocyte adhesion molecules are altered to a greater degree in hypercholesterolemia than serum endothelial adhesion molecules. We examined 29 subjects with hypercholesterolemia and 27 controls at baseline and after 12 weeks of atorvastatin treatment (20 mg/day). Expression of leukocyte integrins CD11a,CD11b, CD18, and CD49d and of L-selectin was measured by flow cytometry. Serum ICAM-1, E-selectin and von Willebrand factor were measured by ELISA. (en)
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Title
| - Leukocyte and endothelial adhesion molecules in patients with hypercholesterolemia : the effect of atorvastatin treatment
- Leukocyte and endothelial adhesion molecules in patients with hypercholesterolemia : the effect of atorvastatin treatment (en)
- Leukocytární a endoteliální adhezivní molekuly u pacientů s hypecholesterolemií : efekt léčby atorvastatinem (cs)
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skos:prefLabel
| - Leukocyte and endothelial adhesion molecules in patients with hypercholesterolemia : the effect of atorvastatin treatment
- Leukocyte and endothelial adhesion molecules in patients with hypercholesterolemia : the effect of atorvastatin treatment (en)
- Leukocytární a endoteliální adhezivní molekuly u pacientů s hypecholesterolemií : efekt léčby atorvastatinem (cs)
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skos:notation
| - RIV/00023736:_____/08:00007661!RIV09-MZ0-00023736
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00023736:_____/08:00007661
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Atherosclerosis; Cell adhesion molecules; Cholesterol; Endothelium; leukocytes (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Marinov, Iuri
- Vrablík, M.
- Češka, R.
- Štulc, T.
- Svobodová, H.
- Kasalová, Z.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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