About: Diamond Blackfan anemia stem cells fail to repopulate erythropoiesis in NOD/SCID mice.     Goto   Sponge   NotDistinct   Permalink

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  • Diamond Blackfan Anemia (DBA) is a congenital disorder characterized by decreased red blood cell production and developmental abnormalities. We herein show that DBA progenitors produced lower numbers of phenotypically normal erythroid colonies in vitro, whereas nonerythroid colonies were normally abundant and developed. To determine whether DBA stem cells are capable of producing early erythroid, monocyto-granulocytic, and lymphoid progenitors in vivo we used a mouse xenotransplantation model. We demonstrate that DBA stem cells poorly repopulated erythroid progeny in NOD/SCID mice, whereas the monocyto-granulocytic and lymphoid progenies were repopulated normally. Therefore, we conclude that disordered DBA erythropoiesis may be a result of defective erythroid-lineage commitment and maintenance of early erythroid progenitors.
  • Diamond Blackfan Anemia (DBA) is a congenital disorder characterized by decreased red blood cell production and developmental abnormalities. We herein show that DBA progenitors produced lower numbers of phenotypically normal erythroid colonies in vitro, whereas nonerythroid colonies were normally abundant and developed. To determine whether DBA stem cells are capable of producing early erythroid, monocyto-granulocytic, and lymphoid progenitors in vivo we used a mouse xenotransplantation model. We demonstrate that DBA stem cells poorly repopulated erythroid progeny in NOD/SCID mice, whereas the monocyto-granulocytic and lymphoid progenies were repopulated normally. Therefore, we conclude that disordered DBA erythropoiesis may be a result of defective erythroid-lineage commitment and maintenance of early erythroid progenitors. (en)
Title
  • Diamond Blackfan anemia stem cells fail to repopulate erythropoiesis in NOD/SCID mice.
  • Diamond Blackfan anemia stem cells fail to repopulate erythropoiesis in NOD/SCID mice. (en)
skos:prefLabel
  • Diamond Blackfan anemia stem cells fail to repopulate erythropoiesis in NOD/SCID mice.
  • Diamond Blackfan anemia stem cells fail to repopulate erythropoiesis in NOD/SCID mice. (en)
skos:notation
  • RIV/00023736:_____/03:00000018!RIV/2004/GA0/L33004/N
http://linked.open.../vavai/riv/strany
  • 93;97
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA301/00/1061), P(NE6689), Z(MSM 111100003), Z(MSM 111100004)
http://linked.open...iv/cisloPeriodika
  • 1
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 603672
http://linked.open...ai/riv/idVysledku
  • RIV/00023736:_____/03:00000018
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Diamond Blackfan anemia; hematopoiesis; erythropoiesis; stem cells; NOD/SCID mice; colony-forming assay (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [D2E98050F133]
http://linked.open...i/riv/nazevZdroje
  • Blood Cells, Molecules and Diseases
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...ocetUcastnikuAkce
http://linked.open...nichUcastnikuAkce
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 31
http://linked.open...iv/tvurceVysledku
  • Pospíšilová, D.
  • Stopka, T.
  • Nečas, E.
  • Živný, J.
  • Jelínek, J.
  • Plašilová, Magdalena
http://linked.open...n/vavai/riv/zamer
issn
  • 1079-9796
number of pages
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