About: The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://content.karger.com/produktedb/produkte.asp?DOI=10.1159/000331562
Description	Background: There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examine the relation between cardiac hypertrophy and survival. Methods: Adult male Wistar rats underwent needle ACF or sham operation and 71 animals surviving the acute procedure with patent ACF were followed for 52 weeks. Results: By the end of the study, 72% of the ACF animals deceased and 82% developed HF signs. Of the HF rats, 65% died (median: 3 weeks after HF onset). Before death, body weight increased by 9% followed by a final drop. 28% ACF rats died suddenly, without preceding HF. Sudden death occurred earlier and in the rats with a trend to larger hearts (p = 0.07). In the whole ACF cohort, heart weight (heart weight/body weight ratio) was inversely associated with the length of survival (r = ?0.51, p ! 0.001). Conclusion: The median survival of ACF Wistar rats is 43 weeks, longer than reported in other rat strains. Increased heart weight is associated with higher mortality and a significant number of animals die suddenly. Background: There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examine the relation between cardiac hypertrophy and survival. Methods: Adult male Wistar rats underwent needle ACF or sham operation and 71 animals surviving the acute procedure with patent ACF were followed for 52 weeks. Results: By the end of the study, 72% of the ACF animals deceased and 82% developed HF signs. Of the HF rats, 65% died (median: 3 weeks after HF onset). Before death, body weight increased by 9% followed by a final drop. 28% ACF rats died suddenly, without preceding HF. Sudden death occurred earlier and in the rats with a trend to larger hearts (p = 0.07). In the whole ACF cohort, heart weight (heart weight/body weight ratio) was inversely associated with the length of survival (r = ?0.51, p ! 0.001). Conclusion: The median survival of ACF Wistar rats is 43 weeks, longer than reported in other rat strains. Increased heart weight is associated with higher mortality and a significant number of animals die suddenly. (en)
Title	The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula (en)
skos:prefLabel	The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula (en)
skos:notation	RIV/00023001:_____/12:00056133!RIV13-MZ0-00023001
http://linked.open...avai/predkladatel	Institut klinické a experimentální mediciny
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(1M0510), P(GA305/09/1390), P(NS10497)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Červenka, Luděk Kopkan, Libor Melenovský, Vojtěch Beneš, Jan Torresová, Věra Škaroupková, Petra
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	128945
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/12:00056133
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Heart failure, Volume overload, Mortality, Cardiac hypertrophy, Experimental models (en)
http://linked.open.../riv/klicoveSlovo	Heart failure Mortality Cardiac hypertrophy Experimental models Volume overload
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[E1E36FBF9FB4]
http://linked.open...i/riv/nazevZdroje	Kidney and Blood Pressure Research
http://linked.open...in/vavai/riv/obor	FA
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for cardiovascular research Investigation of metabolic mechanisms of heart failure progression in an experimental model Metabolic factors involved in progression of chronic heart failure
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	35
http://linked.open...iv/tvurceVysledku	Červenka, Luděk Beneš, Jan Kopkan, Libor Melenovský, Vojtěch Škaroupková, Petra Torresová, Věra
http://linked.open...ain/vavai/riv/wos	000303273500005
issn	1420-4096
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1159/000331562
is http://linked.open...avai/riv/vysledek of	The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula

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