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| rdfs:seeAlso
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| Description
| - Objectives Our goal was to examine the role of B-type natriuretic peptide (BNP) in lipolysis regulation in heart failure (HF) patients. Background: Enhanced adipose tissue lipolysis can contribute to myocardial lipid overload, insulin resistance, and cachexia in advanced HF. Natriuretic peptides were recently recognized to stimulate lipolysis in healthy subjects. Methods: Ten nondiabetic HF patients (New York Heart Association functional class III, 50% nonischemic etiology) and 13 healthy subjects (control subjects) of similar age, sex, and body composition underwent a microdialysis study of subcutaneous abdominal adipose tissue. Four microdialysis probes were simultaneously perfused with 0.1 mu M BNP(1-32), 10 mu M BNP(1-32), 10 mu M norepinephrine (NE) or Ringer's solution. Outgoing dialysate glycerol concentration (DGC) was measured as an index of lipolysis. Results: Spontaneous lipolysis was higher in HF patients compared with control subjects (DGC: 189 +/- 37 mu mol/l vs. 152 +/- 35 mu mol/l, p < 0.01). Response to NE was similar (p = 0.35) in HF patients and control subjects (DGC increase of 1.7 +/- 0.2-fold vs. 1.7 +/- 0.4-fold). BNP(1-32) 10 mu M markedly increased lipolysis in both HF patients and control subjects (DGC increase of 2.8 +/- 0.5-fold vs. 3.2 +/- 0.3-fold), whereas the response to 0.1 mu M BNP(1-32) was more pronounced in HF patients (p = 0.02). In HF patients, spontaneous lipolysis positively correlated with insulin resistance and the response to BNP(1-32) negatively correlated with adiposity. Conclusions: BNP(1-32) exerts strong lipolytic effects in humans. Despite marked elevation of plasma immunoreactive BNP, the responsiveness of adipose tissue to BNP(1-32) is not attenuated in HF, possibly reflecting a deficiency of endogenous bioactive BNP. Lipolytic effects of BNP can contribute to excessive fatty acid mobilization in advanced HF. (J Am Coll Cardiol 2011; 58: 1119-25) (C) 2011 by the American College of Cardiology Founda
- Objectives Our goal was to examine the role of B-type natriuretic peptide (BNP) in lipolysis regulation in heart failure (HF) patients. Background: Enhanced adipose tissue lipolysis can contribute to myocardial lipid overload, insulin resistance, and cachexia in advanced HF. Natriuretic peptides were recently recognized to stimulate lipolysis in healthy subjects. Methods: Ten nondiabetic HF patients (New York Heart Association functional class III, 50% nonischemic etiology) and 13 healthy subjects (control subjects) of similar age, sex, and body composition underwent a microdialysis study of subcutaneous abdominal adipose tissue. Four microdialysis probes were simultaneously perfused with 0.1 mu M BNP(1-32), 10 mu M BNP(1-32), 10 mu M norepinephrine (NE) or Ringer's solution. Outgoing dialysate glycerol concentration (DGC) was measured as an index of lipolysis. Results: Spontaneous lipolysis was higher in HF patients compared with control subjects (DGC: 189 +/- 37 mu mol/l vs. 152 +/- 35 mu mol/l, p < 0.01). Response to NE was similar (p = 0.35) in HF patients and control subjects (DGC increase of 1.7 +/- 0.2-fold vs. 1.7 +/- 0.4-fold). BNP(1-32) 10 mu M markedly increased lipolysis in both HF patients and control subjects (DGC increase of 2.8 +/- 0.5-fold vs. 3.2 +/- 0.3-fold), whereas the response to 0.1 mu M BNP(1-32) was more pronounced in HF patients (p = 0.02). In HF patients, spontaneous lipolysis positively correlated with insulin resistance and the response to BNP(1-32) negatively correlated with adiposity. Conclusions: BNP(1-32) exerts strong lipolytic effects in humans. Despite marked elevation of plasma immunoreactive BNP, the responsiveness of adipose tissue to BNP(1-32) is not attenuated in HF, possibly reflecting a deficiency of endogenous bioactive BNP. Lipolytic effects of BNP can contribute to excessive fatty acid mobilization in advanced HF. (J Am Coll Cardiol 2011; 58: 1119-25) (C) 2011 by the American College of Cardiology Founda (en)
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| Title
| - Lipolytic effects of B-Type natriuretic peptide(1-32) in adipose tissue of heart failure patients compared with healthy controls
- Lipolytic effects of B-Type natriuretic peptide(1-32) in adipose tissue of heart failure patients compared with healthy controls (en)
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| skos:prefLabel
| - Lipolytic effects of B-Type natriuretic peptide(1-32) in adipose tissue of heart failure patients compared with healthy controls
- Lipolytic effects of B-Type natriuretic peptide(1-32) in adipose tissue of heart failure patients compared with healthy controls (en)
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| skos:notation
| - RIV/00023001:_____/11:00002471!RIV12-MZ0-00023001
|
| http://linked.open...avai/predkladatel
| |
| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(1M0510), P(GA305/09/1390), P(NS10497), Z(MSM0021620814), Z(MZ0IKEM2005)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/00023001:_____/11:00002471
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - B-type natriuretic peptide; free fatty acids; heart failure; insulin resistance; lipolysis (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Journal of the American College of Cardiology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Kautzner, Josef
- Polák, Jan
- Málek, Ivan
- Jabor, Antonín
- Melenovský, Vojtěch
- Kazdová, Ludmila
- Kotrč, Martin
- Wedellová, Z.
|
| http://linked.open...ain/vavai/riv/wos
| |
| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://bibframe.org/vocab/doi
| - 10.1016/j.jacc.2011.05.042
|
| is http://linked.open...avai/riv/vysledek
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