About: Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Aims: Therapeutic administration of retinoids is often accompanied with undesirable side effects, including an increase in lipid levels in up to 45% of treated patients. We tested the hypothesis of whether spontaneously hypertensive rat (SHR) and congenic SHR.PD-(D8Rat42-D8Arb23)/Cub (SHR-Lx) strains, differing only in a 14-gene region of chromosome 8 and previously shown to display differential sensitivity to the teratogenic effects of retinoic acid, could serve as a pharmacogenetic model set of the metabolic side effects of retinoid therapy. Materials & methods: Male, 15-week old rats (n = 12/strain) of SHR and SHR-Lx strains were fed a high-sucrose diet for 2 weeks and subsequently treated either with all-trans retinoic acid (15 mg/kg) or only with a vehicle for 16 days (n = 6/strain/treatment), while still on the high-sucrose diet. We assessed the morphometric and metabolic profiles of all groups, including glucose tolerance tests, levels of insulin, adiponectin, free fatty acids, concentratio Aims: Therapeutic administration of retinoids is often accompanied with undesirable side effects, including an increase in lipid levels in up to 45% of treated patients. We tested the hypothesis of whether spontaneously hypertensive rat (SHR) and congenic SHR.PD-(D8Rat42-D8Arb23)/Cub (SHR-Lx) strains, differing only in a 14-gene region of chromosome 8 and previously shown to display differential sensitivity to the teratogenic effects of retinoic acid, could serve as a pharmacogenetic model set of the metabolic side effects of retinoid therapy. Materials & methods: Male, 15-week old rats (n = 12/strain) of SHR and SHR-Lx strains were fed a high-sucrose diet for 2 weeks and subsequently treated either with all-trans retinoic acid (15 mg/kg) or only with a vehicle for 16 days (n = 6/strain/treatment), while still on the high-sucrose diet. We assessed the morphometric and metabolic profiles of all groups, including glucose tolerance tests, levels of insulin, adiponectin, free fatty acids, concentratio (en)
Title	Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance (en)
skos:prefLabel	Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance (en)
skos:notation	RIV/00023001:_____/10:00002389!RIV11-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/06/0116), P(NR9387), Z(MSM0021620807), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Kazdová, Ludmila Šeda, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	333253
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/10:00002389
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	cholesterol; comparative genomics; congenic strain; insulin resistance; metabolic syndrome; retinoid; SHR; triglyceride (en)
http://linked.open.../riv/klicoveSlovo	retinoid comparative genomics congenic strain cholesterol insulin resistance metabolic syndrome SHR triglyceride
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[FDD2D2180C5F]
http://linked.open...i/riv/nazevZdroje	Pharmacogenomics
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of adipocytokines and fatty acids in the disorders of insulin sensitivity and insulin secretion in metabolic syndrome Genes influencing limb patterning: morphology and functional genomics of hypodactyly and polydactyly-luxate mutations in the Norway rat
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Kazdová, Ludmila Liska, F. Šedová, L. Šeda, Ondřej Janků, M. Křen, V. Křenová, D. Krupková, M.
http://linked.open...ain/vavai/riv/wos	000272767800011
http://linked.open...n/vavai/riv/zamer	Metabolické, endokrinní a genetické aspekty prevence, diagnostiky a terapie kardiovaskulárních, cerebrovaskulárních a renovaskulárních onemocnění Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	1462-2416
number of pages	13 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance Pharmacogenetic model of retinoic acid-induced dyslipidemia and insulin resistance

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