About: CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Human renal epithelial cells might play an important role during the allograft rejection by producing chemokines in response to proinflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β produced by endothelial and epithelial cells early after transplantation. The production of chemokines allows inflammatory cells to be drawn into the kidney graft and therefore plays a critical role in the pathophysiologic processes that lead to the rejection of renal transplant. In this process, two chemokine superfamilies, the CC and the CXC chemokines, are the most important. The CC chemokines target mainly monocytes and T lymphocytes, while most of the CXC chemokines attract neutrophils. We showed in our study that in vitro, in unstimulated cells, basal mRNA expression of CXC chemokines (Groα, Groβ, Groγ, ENA-78 and GCP-2, IL-8) that attract neutrophils was detectable and expression of these genes and chemokine release were increased in TNF-α- and IL-1 Human renal epithelial cells might play an important role during the allograft rejection by producing chemokines in response to proinflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β produced by endothelial and epithelial cells early after transplantation. The production of chemokines allows inflammatory cells to be drawn into the kidney graft and therefore plays a critical role in the pathophysiologic processes that lead to the rejection of renal transplant. In this process, two chemokine superfamilies, the CC and the CXC chemokines, are the most important. The CC chemokines target mainly monocytes and T lymphocytes, while most of the CXC chemokines attract neutrophils. We showed in our study that in vitro, in unstimulated cells, basal mRNA expression of CXC chemokines (Groα, Groβ, Groγ, ENA-78 and GCP-2, IL-8) that attract neutrophils was detectable and expression of these genes and chemokine release were increased in TNF-α- and IL-1 (en)
Title	CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines (en)
skos:prefLabel	CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines (en)
skos:notation	RIV/00023001:_____/09:00002110!RIV10-MZ0-00023001
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(NR8276), Z(AV0Z50200510), Z(MZ0IKEM2005)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Jarešová, Marcela Brabcová, Eva Kolesár, Libor Stříž, Ilja Slavčev, Antonij
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Institut klinické a experimentální medicíny
http://linked.open...dnocenehoVysledku	308756
http://linked.open...ai/riv/idVysledku	RIV/00023001:_____/09:00002110
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	epithelial cells; chemokines; transplantation; renal allograft; acute rejection (en)
http://linked.open.../riv/klicoveSlovo	acute rejection renal allograft transplantation chemokines epithelial cells
http://linked.open...odStatuVydavatele	DK - Dánské království
http://linked.open...ontrolniKodProRIV	[3733C74F31EB]
http://linked.open...i/riv/nazevZdroje	APMIS: Acta pathologica, microbiologica et immunologica Scandinavica
http://linked.open...in/vavai/riv/obor	FN
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	The role of renal epithelium and gene polymorphisms of proinflammatory cytokines in allograft rejection
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	117
http://linked.open...iv/tvurceVysledku	Brabcová, Eva Jarešová, Marcela Kolesár, Libor Slavčev, Antonij Stříž, Ilja Thorburn, E. Petricek, M. Petrickova, K.
http://linked.open...ain/vavai/riv/wos	000267315400001
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Výzkum kardiovaskulárních nemocí, diabetu a transplantace životně důležitých orgánů
issn	0903-4641
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines CXC and CC chemokines induced in human renal epithelial cells by inflammatroy cytokines

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