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| Description
| - V předkládaném projektu budou řešeny otázky vztahů mezi strukturou a vlastnostmi polysacharidů mucinového typu a jejich syntetických derivátů. Budou připraveny antigeny T, Tn a sTn a jejich strukturní modifikace. Dále budou studovány mechanismy reakcí peptidů a aminokyselin s Pt(II) a Pd(II). Budou připraveny komplexy lanthanoidů s makrocyklickými ligandy a studována možnost využití těchto komplexů jako posuvových činidel v NMR.
- One of the most rapidly advancing area of the biomedicinal research deals with study of relationship between chemical structure and biological activity. This research is currently facilitated by methods of modern structural analysis , mainly NMR and MS .In the framework of this project, we intend to pay an attention to following problems: I. Study of th mucine-type polysaccharides and their synthetic derivatives. Antigens of T, Tn and sTn will be synthesized on the polymeric resin. II. Study of mechanisms of Pt(II) and Pd(II) reactions with aminoacids and oligopeptides which is related to mechasism of action of %22cisplatinum%22 III. Preparation and study of complexes of lanthanoides with macrocyclic ligands These comlexes may act as a shift reagents in the NMR spectroscopy or can be used in the study of biological materials. (en)
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| Title
| - Preparation and study of biologically active biopolymers and selected model-compounds (en)
- Příprava a studium biologicky aktivních biopolymerů a vybraných modelových látek
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open.../cep/klicovaSlova
| - NMR spectroscopy, Tn antigens, glycopeptides, mucine-type polysacharydes, macrocycles, (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...jektu+dodavatelem
| - Bylo vytvořeno nové pracoviště zaměřené na výzkum v oblasti látek použitelných pro terapii a diagnostiku nádorových onemocnění. Získané výsledky byly publikovány v mezinárodních odborných časopisech a prezentovány na domácích i zahr. konferencích. (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - NMR spectroscopy
- macrocycles
- Tn antigens
- glycopeptides
- mucine-type polysacharydes
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| is http://linked.open...vavai/riv/projekt
of | - Komplexy aminoalkylfosfonových kyselin a fosfonodipeptidů s Pt(II) a Pd(II)
- Komplexy platiny a palladia s aminomethylfosfonovou kyselinou a glycylaminomethylfosfonovou kyselinou
- Complexing Properties of Diastereoisomeres of 1-(L-methionylamino)-ethylphosphonic Acid
- Lanthanide complexes of a cyclen derivate with phenylphosphinic pendant arms for possible 1H and 31P MRI temperature sensitive probes.
- Synthetic Glycopeptide Dendrimers with Tn Antigenic Structure: Immunobiological Study II.
- Synthesis, crystal structures and NMR and luminescence spectra of lanthanide complexes of 1,4,7,10-tetraazacyclododecane with N-methylene(phenyl)phosphinic acid pendant arms
- Bis(methylphosphonic Acid) Derivatives of 1,4,8,11-tetraazacyclotetradecane. (Cyclam). Synthesis, Crystal and Molecular Structure, and Solution Properties.
- Crystal Structures and Reactivity of 3a,5a,8a,10a-Tetraazaperhydropyrene Derivatives. An Alternative Approach to Selective Nitrogen Alkylation of 1,4,8,11-Tetraazacyclotetradecane (Cyclam)
- Preparation and conformational analysisi of 1,2-seco derivatives of 19b,28-epoxy-18a-oleanane
- Thermodynamic and kinetic study of copper(II) complexes with N-methylene(phenylphosphinic acid) derivatives of cyclen and cyclam
- Synthesis, Crystal Structures, and Solution Properties of N-Methylene(phenyl)phosphinic Acid Derivatives of Cyclen and Cyclam
- Synthesis of unstaturated sulfur-linked (1-4)-disaccharides by substitution of tosyloxygroup in 1,6-anhydro-3,4-dideoxy-2-O-tosyl-beta-D-erythro-hex-3-enopyranose with 1-thiohexopyraboses
- Synthesis and NMR spectra of 1,6-anhydro-2,3-epimino- and 1,6-anhydro-3,4-epimino-beta-D-hexopyranoses
- An NMR study of a unique P,C-coordination of 2-dimethylamino-2'-diphenylphosphino-1,1'-binaphthyl (MAP) to palladium.
- Multiple Antigenic Glycopeptides Carrying Tn Antigens: Structure-Activity Correlations
- Derivative of Cyclen with Three Methylene(phenyl)Phosphinic Acid Pendant Arms. Synthesis and Crystal Structures of its Lanthanide Complexes.
- Nucleophilic Reactivity of Perhydro-3,6,9,12-tetraazacyclopenteno[1,3-f,g]acenaphthylene. A Unified Aproach to N-Monosubstituted and N,N''-Disubstituted Cyclene Derivatives
- Selective N-debenzylation pf benzylaminoderivatives pf 1,6.anhydro-beta-D-hexopyranoses
- The cis/trans-isomerism on cobalt(III) complexes with 1,4,8,11-tetraazacyclotetradecane- 1,8-bis(methylphosphonic acid)
- Copper(II)-mediated oxidative coupling of 2-aminonaphthalene homologues. Competition between the straight dimerization and the formation of carbazoles
- Computational and NMR study of multiple antigenic glycopeptides (MAGs) with Tn antigens.
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| is http://linked.open...vavai/cep/projekt
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