About: Center for Development of Original Drugs

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=TE01020028
Description	The project Center for development of original drugs is strategic plan utilizing results of research in medicinal chemistry and pharmacology. The goal is to enable the transfer of drug candidates into a commercial practice. The project will create a structure which will be able to evolve novel drugs mainly in the pre-clinical phase. The project will increase the success rate of the original drugs development in Czech Republic and will continue this field of local research and industry. (en) Projekt Centrum vývoje originálních léčiv je strategickým plánem, který zhodnocuje výsledky základního výzkumu v oblastech medicinální chemie a farmakologie. Cílem projektu je umožnit převod lékových kandidátů do komerční praxe. Projekt vytvoří organizační strukturu schopnou rozvíjet projekty zaměřené na hledání nových léků především v preklinickém stádiu. Projekt zásadním způsobem zvýší úspěšnost vývoje originálních léků v ČR a bude pokračovatelem v tradičně silném oboru místní vědy a průmyslu.
Title	Center for Development of Original Drugs (en) Centrum vývoje originálních léčiv
skos:notation	TE01020028
http://linked.open...avai/cep/aktivita	Competence Centres
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/TE01020028/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/TE01020028/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2015-05-26 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	C - Předmět podléhá obchodnímu tajemství (§17 až 20 Obchodního zákoníku), ale některé údaje jsou upraveny tak, aby byly zveřejnitelné
http://linked.open.../cep/fazeProjektu	100995054
http://linked.open...ai/cep/hlavniObor	CC - Organická chemie
http://linked.open...vai/cep/kategorie	AP - Aplikovaný výzkum
http://linked.open.../cep/klicovaSlova	medicinal chemistry, original drug development, collitis, alzheiemer, cancer, HIV, neurodegeneration, inflamation, autoimmunity, pharmaco-dynamics, pharmaco-kinetics, toxicity, genotoxicity, ADME, pharmacology (en)
http://linked.open...ep/partnetrHlavni	Ústav organické chemie a biochemie AV ČR, v. v. i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	8 (xsd:int)
http://linked.open.../pocetVysledkuRIV	26 (xsd:int)
http://linked.open...enychVysledkuVRIV	26 (xsd:int)
http://linked.open...lneniVMinulemRoce	2014-03-03 (xsd:date)
http://linked.open.../prideleniPodpory	http://linked.opendata.cz/resource/domain/vavai/cep/prideleniPodpory/2012TE01020028
http://linked.open...iciPoslednihoRoku	2015
http://linked.open...atUdajeProjZameru	2015
http://linked.open.../vavai/cep/soutez	STA02012CK
http://linked.open...usZobrazovaneFaze	DRRVB
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open...ep/ukonceniReseni	2019-12-31 (xsd:date)
http://linked.open.../cep/vedlejsiObor	FR - Farmakologie a lékárnická chemie CE - Biochemie
http://linked.open...ep/zahajeniReseni	2012-04-01 (xsd:date)
http://linked.open...tniCyklusProjektu	ZBBB
http://linked.open.../cep/klicoveSlovo	medicinal chemistry ADME HIV autoimmunity cancer genotoxicity toxicity alzheiemer collitis inflamation neurodegeneration original drug development pharmaco-dynamics pharmaco-kinetics
is http://linked.open...vavai/riv/projekt of	alpha-Methoxymethyl ketones via aldol reaction METHOD OF PREPARATION AND ISOLATION OF BETULIN DIACETATE FROM BIRCH BARK FROM PAPER MILLS AND ITS OPTIONAL PROCESSING TO BETULIN METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION Carborane-based carbonic anhydrase inhibitors Derivatives 2-phenyl-3-hydroxyquinoline-4(1H)-ones and methods of their preparation and utilization Deriváty pregnanolonu substituované v poloze 3alfa kationickou skupinou, způsob jejich výroby, jejich použití a prostředek je obsahující Vyšetření cytogenetických změn metodou fluorescenční in situ hybridizace Examination of epithelial gene and oncogene expression by real-time reverse transcriptase polymerase chain reaction method Vyšetření mutací a polymorfismů genu KRAS, EGFR, BRAF polymerázovou řetězovou reakcí s detekcí v reálném čase Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides Structure, function, and pharmacology of NMDA receptor channels METHOD OF PREPARATION AND ISOLATION OF BETULIN DIACETATE FROM BIRCH BARK FROM PAPER MILLS AND ITS OPTIONAL PROCESSING TO BETULIN METHOD FOR DETERMINING THE SENSITIVITY OF PATIENTS SUFFERING FROM A CANCER DISEASE TO BIOLOGICAL THERAPY METHOD FOR DETERMINING THE SENSITIVITY OF PATIENTS SUFFERING FROM A CANCER DISEASE TO BIOLOGICAL THERAPY METHOD OF PREPARATION OF A SOLUBLE FORMULATION OF WATER-INSOLUBLE PENTACYCLIC AND TETRACYCLIC TERPENOIDS, A SOLUBLE FORMULATION OF A PENTACYCLIC OR TETRACYCLIC TERPENOID AND A PHARMACEUTICAL COMPOSITION CONTAINING THIS SOLUBLE FORMULATION Carborane-based carbonic anhydrase inhibitors: insight into CAII/CAIX specificity from a high-resolution crystal structure, modeling, and quantum chemical calculations Synthesis and cytotoxicity of some D-mannose click conjugates with aminobenzoic acid derivatives On the solubility and lipophilicity of metallacarborane pharmacophores Pregnenolone sulfate activates NMDA receptor channels Neuroactive steroids with perfluorobenzoyl group Neuroprotective effect of the 3 alpha 5 beta-pregnanolone glutamate treatment in the model of focal cerebral ischemia in immature rats Novel cytostatic 7-deazapurine nucleosides Novel cytostatic 7-deazapurine nucleosides Pregnanolone glutamate, a novel use-dependent NMDA receptor inhibitor, exerts antidepressant-like properties in animal models Anionic pregnane compounds, method for their producing and use of them Method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, a soluble formulation of a pentacyclic or tetracyclic terpenoid and a pharmaceutical composition containing this soluble formulation
is http://linked.open...vavai/cep/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2012/ico%3A25074555 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2012/ico%3A25926713 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2012/ico%3A28934024 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2012/ico%3A61388963 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2012/ico%3A64938255 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2012/ico%3A67985823 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2012/ico%3A68378041 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2012/orjk%3A15110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2012/orjk%3A22340 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2013/ico%3A25074555 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2013/ico%3A25926713 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2013/ico%3A28934024 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2013/ico%3A61388963 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2013/ico%3A64938255 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2013/ico%3A67985823 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2013/ico%3A68378041 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2013/orjk%3A15110 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2013/orjk%3A22340 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2014/ico%3A25074555 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2014/ico%3A25926713 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2014/ico%3A28934024 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2014/ico%3A61388963 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2014/ico%3A64938255 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2014/ico%3A67985823 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/TE01020028/2014/ico%3A68378041

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