About: Biorecognizable polymer conjugates with anticancer activity.

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About: Biorecognizable polymer conjugates with anticancer activity. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
rdfs:seeAlso	http://www.isvav.cz/projectDetail.do?rowId=PZ-Z2/24
Description	New generation compounds targeted against primary colorectal, carcinoma and verification of their use in treatment of metastases. The treatment is based on a combined therapy utilizing 5-fluorouracil and metothrexate. (en) Příprava nové generace léčiv namířených proti primárnímu kolorektálnímu karcinomu a ověření možnosti jejich použití pro léčbu metastáz. Tento způsob léčby je založen na kombinované terapii s použitím 5-fluorouracilu a metotrexátu.
Title	Biorecognizable polymer conjugates with anticancer activity. (en) Polymerní biokonjugáty s protinádorovou aktivitou.
skos:notation	PZ-Z2/24
http://linked.open...avai/cep/aktivita	Schemes commenced in 1997
http://linked.open...kovaStatniPodpora	http://linked.opendata.cz/resource/domain/vavai/projekt/PZ-Z2%2F24/celkovaStatniPodpora
http://linked.open...ep/celkoveNaklady	http://linked.opendata.cz/resource/domain/vavai/projekt/PZ-Z2%2F24/celkoveNaklady
http://linked.open...datumDodatniDoRIV	2002-12-19 (xsd:date)
http://linked.open...i/cep/druhSouteze	VS - Veřejná soutěž ve výzkumu a vývoji
http://linked.open...ep/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open.../cep/fazeProjektu	890050
http://linked.open...ai/cep/hlavniObor	FR - Farmakologie a lékárnická chemie
http://linked.open...hodnoceniProjektu	U - Uspěl podle zadání, tj. byly splněny cíle a jeho předpokládané výsledky uvedené ve smlouvě / rozhodnutí o poskytnutí podpory
http://linked.open.../cep/klicovaSlova	targeted drugs; colorectal carcinoma; matastasis; 5-fluorouracil; metothrexate (en)
http://linked.open...ep/partnetrHlavni	Mikrobiologický ústav AV ČR, v.v.i.
http://linked.open...inujicichPrijemcu	0 (xsd:int)
http://linked.open...cep/pocetPrijemcu	1 (xsd:int)
http://linked.open...ocetSpoluPrijemcu	1 (xsd:int)
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http://linked.open...enychVysledkuVRIV	14 (xsd:int)
http://linked.open...iciPoslednihoRoku	2002
http://linked.open...atUdajeProjZameru	2002
http://linked.open...usZobrazovaneFaze	DUU
http://linked.open...ai/cep/typPojektu	P - Projekt výzkumu a vývoje financovaný ze státního rozpočtu
http://linked.open.../cep/vedlejsiObor	CD - Makromolekulární chemie FN - Epidemiologie, infekční nemoci a klinická imunologie
http://linked.open...jektu+dodavatelem	Cíle projektu splněny. Polymerní konjugát cytostatického léčiva, obsahující lidský imunoglobulin, byl použit v předběžném klinickém testování u dou pacientek s generalizovaným karcinomem prsu. (cs)
http://linked.open...tniCyklusProjektu	ZBBBKU
http://linked.open.../cep/klicoveSlovo	targeted drugs 5-fluorouracil colorectal carcinoma matastasis
is http://linked.open...vavai/riv/projekt of	Immunocompatibility and biocompatibility of cell delivery systems. New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. Acquired and specific immunological mechanisms co-responsible for efficacy of polymer-bound drugs Computer modelling of 5-fluorouracil conjugate with an N-(2-hydroxypropyl)methacrylamide copolymer in an active cleft of the cathepsin B. Use of 'star-like' macromolecular prodrugs in cancer therapy. Polymeric bioconjugates with anti-cancer effects - A final report of Project PZ-Z2/24. 'Star-like' structure of antibody-targeted HPMA copolymers-bound doxorubicin:binding, in vitro cytostatic activity and anti-tumor effect against BCL1 leukemia in vivo. In Vitro and In Vivo Effect of HPMA Copolymer-bound Doxorubicin Targeted to Transferrin Receptor of B-cell Lymphoma 38C13. Antiproliferative effect of a lectin- and anti-Thy-1.2 antibody-targeted HPMA copolymer-bound doxorubicin on primary and metastatic human colorectal carcinoma and on human colorectal carcinoma transfected with the mouse Thy-1.2 gene. Polymeric drugs based on conjugates of synthetic and natural macromolecules. II. Anti-cancer activity of antibody or (Fab')2-targeted conjugates and combined therapy with immunomodulators. Doxorubicin bound to a HPMA copolymer carrier through hydrazone bond is effective also in a cancer cell line with a limited content of lysosomes. Immunoprotective therapy with targeted anticancer drugs. The influence of a colonic microbiota on HPMA copolymer lectin conjugates binding in rodent intestine. Synthesis of HPMA copolymers containing doxorubicin bound via a hydrazone linkage. Effect of spacer on drug release and in vitro cytotoxicity.
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