About: Capillary leak syndrom. Importance for farmakokinetics and toxicokinetics of gentamicin.     Goto   Sponge   NotDistinct   Permalink

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  • Capillary leak syndrome (CLS) is characterized by an increase in vascular permeability accompained by extravasation of fluids and proteins from the capillary vessels into the tissues resulting in interstitial edema, decrease in microcirculatory pefusion and different types and severities of organ damage. CLS was observed in various pathological conditions- it occurs in patiens with sepsis, burns, trauma, surgery and other disease, in cancer patients treated with interleukon -2,-3-4, immunotoxins, GM-CSF, and cytostatics. Recently we have found that CLS in 37% of neonates critically ill treated with gentamicin (Ge) during the first postnatal week, CLS makes kinetically guided Ge dosage prediction impossible. It may be due to significant changes in the PK of Ge that is distributed to extravascular fluid and eliminated via glomerular filtration, and whose efficacy, moreover, is more dependent on plasma concentration than on the dosing. The project is focused on 1. development of experimental CLS, 2. (en)
  • Validovaná a reprodukovatelná experimentální metoda navození capillary leak syndromu u malého laboratorního zvířete spolu s kriteriemi objektivního vyhodnocení typu syndromu a jeho závažnosti.
Title
  • Capillary leak syndrom. Importance for farmakokinetics and toxicokinetics of gentamicin. (en)
  • Capillary leak syndrome a jeho význam pro kinetiku a dynamiku modelových léčiv.
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  • OC09071
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  • Capillary leak syndrome; experimental methods; pharmacokinetics of gentamicin (en)
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  • Were established dose of lipopolysacharide and interleukin-2 to induce sepsis with capillary leakage. Volume of distribution was increased in experimental rats compared with controls, but the elimination halftime was shorter in LPSIL-2 rats and clearence per kg was increasedin LPSIL-2 animals. (en)
  • Podařilo se nastavit dávku LPS a IL-2 k vyvolání rané sepse s kapilárním leakem. Farmakokineticky byl distribuční objem u experimentálních potkanů zvětšený v porovnání s kontrolami, ale biologický poločas vychází kratší a celková clearence na kg byla vyšší u LPSIL-2 potkanů. (cs)
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  • experimental methods
  • Capillary leak syndrome
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