About: A role of B lymphocytes in immune reactions after kidney transplantation     Goto   Sponge   NotDistinct   Permalink

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Description
  • In this project, we will investigate the role of B-lymphocytes phentotypes and their transcripts in peripheral blood and the donor specific antibodies in alloimune response in the cohort of kidney transplant recipients, and in experimental models by means of molecular genetic and immunological methods. We assume that the specific populations of B-lymphocytes and their transcripts will be associated with the absence of rejection, whereas others with the rejection of grafts. The project can so help to identify new biomarkers applicable for the future validation in clinical studies with the objective to individualize the immunosuppressive therapy. (en)
  • V tomto projektu budeme pomocí molekulárně genetických a imunologických metod zkoumat roli fenotypů B lymfocytů a jejich transkriptů v periferní krvi a dárcovsky specifických protilátek při alloimunitní odpovědi v kohortě nemocných po transplantaci ledviny a v experimentálních modelech. Předpokládáme, že specifické populace B lymfocytů a jejich transkripty budou asociovány s absencí rejekce, kdežto jiné s odhojením štěpů. Projekt tak může pomoci identifikovat nové biomarkery použitelné pro budoucí validaci v klinických studiích s cílem individualizovat imunosupresivní terapii.
Title
  • A role of B lymphocytes in immune reactions after kidney transplantation (en)
  • Role B lymfocytů v imunitních reakcích po transplantaci ledviny
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  • NT14102
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  • kidney transplantation; B cell; RT-PCR; antibodies; tolerance; lymphocyte; transcript (en)
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  • kidney transplantation
  • RT-PCR
  • antibodies
  • tolerance
  • B cell
  • lymphocyte
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