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| Description
| - The adhesive properties of leukemia cells and cell lines derived from chronic myelogenous leukemia (CML) K562, JURL-MK1, to the extracellular matrix compounds (fibronectin, collagen, laminin, vitronectin) will be studied. Using differential proteomic analysis the mechanism will be studied of the effects of inhibitors of BCR-ABL tyrosine kinase activity, of proteasome, HSP90 chaperonic activity and histone deacetylases, on the proteins of CML cells adhesion apparatus. By means of interaction proteomics the signaling pathways will be identified which are responsible for defective adhesion of CML cells, and the molecular mechanism would be derived of the effects of the above substances on the adhesive properties. (en)
- Budou studovány adhezní vlastnosti leukemických buněk a buněčných linií odvozených od chronické myeloidní leukemie (CML: K562, JURL-MK1) k modelové extracelulární matrici kostní dřeně (fibronektin, kolagen, laminin, vitronektin). Diferenční proteomovou analýzou bude studován mechanismus účinků inhibitoru kinázové aktivity BCR-ABL, inhibitoru proteasomu, inhibitoru chaperonové aktivity HSP90, inhibitoru histondeacetyláz, na komponenty adhezního aparátu CML buněk. Metodami interakční proteomiky budou identifikovány signální dráhy zodpovědné za porušenou adhezi leukemických buněk CML a bude navržen molekulární mechanismus na úrovni proteinů účinku uvedených látek na adhezní vlastnosti.
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| Title
| - Study of the disturbancies of cell adhesion regulation in hematological malignancies (en)
- Studium poruch regulace buněčné adheze u hematologických malignit
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - adhesion signaling; extracellular matrix; chronic myelogenous leukemia; focal adhesion; cytoskeleton; proteomics; mass spectrometry (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - New information on pathobiology of CML (en)
- Nové poznatky z oblasti patobiologie CML (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - cytoskeleton
- extracellular matrix
- proteomics
- chronic myelogenous leukemia
- focal adhesion
- adhesion signaling
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| is http://linked.open...vavai/riv/projekt
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| is http://linked.open...vavai/cep/projekt
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