About: SELECTED NUTRITIONAL AND GENETIC FACTORS IN THE PATHOGENESIS OF METABOLIC SYNDROME AND DEPRESSIVE DISORDERS     Goto   Sponge   NotDistinct   Permalink

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  • The interactions between components of metabolic syndrome and depression, dietary pattern, profiles of PUFA in plasma lipids, homocysteine, parameters of oxidative stress as well as inflammation, selected cytokines and BDNF in serum will be analysed. The hypothesis about the causal relation between the deficiency of PUFA n-3, high homocysteine, oxidative stress in development of metabolic syndrome and depression and effect of selected genetic polymorphisms on these relations will be tested. (en)
  • Budou analyzovány vztahy mezi komponentami metabolického syndromu a depresí, složením diety, koncentracemi PUFA v lipidech plazmy, homocysteinu, ukazateli oxidačního stresu a zánětu, vybranými cytokiny a mozkovým neurotrofickým faktorem v séru Bude testována hypotéza o kauzálním vztahu mezi deficiencí PUFA n-3, zvýšenou koncentrací homocysteinu, oxidačním stresem při rozvoji metabolického syndromu a deprese a vlivu vybraných genetických polymorfizmů na tyto vztahy.
Title
  • SELECTED NUTRITIONAL AND GENETIC FACTORS IN THE PATHOGENESIS OF METABOLIC SYNDROME AND DEPRESSIVE DISORDERS (en)
  • VYBRANÉ NUTRIČNÍ A GENETICKÉ FAKTORY V PATOGENEZE METABOLICKÉHO SYNDROMU A DEPRESIVNÍCH PORUCH
skos:notation
  • NR8806
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  • metabolic syndrome; depression; PUFA n-3; homocysteine; oxidative stres; BDNF; genetic polymorphisms; inflammation (en)
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  • Cíle tohoto projektu splněny v termínu, ale s omezeným počtem pacientů s depresivní poruchou (n=41), což omezuje validitu genetických vyšetření.Na základě 4 publikací v časopisech s IF se však přikláním ke kategorii A (cs)
  • The project´s targets were fulfilled in time but with limited number of depresive subjects (n=41). This could lead to falsely positive results of genetic analysis.Nevertheless, on the basis of 4 publications in journals with IF I suggest evaluation A. (en)
http://linked.open...tniCyklusProjektu
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  • metabolic syndrome
  • depression
  • homocysteine
  • BDNF
  • PUFA n-3
  • genetic polymorphisms
  • oxidative stres
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