About: Structural studies of transcriptional regulators of the DeoR and GntR families involved in catabolic repression in Bacillus subtilis.     Goto   Sponge   NotDistinct   Permalink

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  • In many bacteria, the expression of the genes involved in the metabolism of secondary carbon sources is typically repressed in the presence of the most favorable nutrient. This mechanism of regulation, designated carbon catabolite repression, has been extensively studied in B. subtilis. It requires participation of numerous specific repressors and activators controlling the level of transcription of catabolic genes. Transcriptional repressors involved in catabolic repression mainly belong to one of the two large families of prokaryotic transcriptional regulators, GntR and DeoR, respectively. Members of these families share an N-terminal helix-turn-helix DNA-binding domain and and structurally dissimila C-terminal domains that are involved in effector binding and oligomerization. We have recently determined crystal structures of the effector binding domains of two transcriptional repressors from B. subtilis, CggR (central glycolytic genes regulator) and TreR (trehalose operon repressor), belonging t (en)
  • Cílem projektu je získat strukturní informaci o skupině transkripčních represorů účastnících se katabolické represe v bakterii Bacillus subtilis. K určení struktur využijeme metod rentgenové krystalografie.
Title
  • Structural studies of transcriptional regulators of the DeoR and GntR families involved in catabolic repression in Bacillus subtilis. (en)
  • Strukturní studie transkripčních regulátorů rodiny DeoR a GntR účastnících se katabolické represe v bakterii Bacillus subtilis.
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  • ME08016
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  • Transciptional repressor; catabolic repression; Bacillus subtilis; protein crystallography; X-ray crystallography; 3-D structure; crystal structure (en)
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  • Cílem pětiletého projekt bilaterální spolupráce bylo získat strukturní informaci o skupině transkripčních regulátorů účastnících se kataboiické represe v bakterii Bacillus subtilis. Výsledkem projektu je šest trojrozměrných struktur represorů CggR, AraR a DeoR. Získané výsledky, které výrazně přispěly k pochopení mechanismů genové regulace, byly publikovány v odborných publikacích. (cs)
  • The aim of a five-year project of bilateral collaboration was to obtain structural information on group of transcriptional regulators in bacteria Bacilus subtilis. Six three-dimensional structures of CggR, AraR and DeoR repressors were determined. Obtained results, which are crucial for understanding mechanisms of gene regulation, were published in scientific journals. (en)
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  • Bacillus subtilis
  • X-ray crystallography
  • protein crystallography
  • 3-D structure
  • catabolic repression
  • Transciptional repressor
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