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| Description
| - The project is directed to the improvement of diagnostic techniques in oncology both in primary diseases and in related infections. The development of high-resolution cytometric techniques and methods of the detection of the telomerase activity will be the goals of the project. Topographic characteristics of appropriate genetic loci in selected tumour tissues will be mesured and correlated to tumour characteristcs. The development of techniques and methods for clinical applications will be followed by industrial development of a confocal cytometr. In addition, methods of detection of the telomerase activity and expresion will be optimised both for the diagnostic purposes, and for testing the sensitivity of cultured tumor cells to cytostatics and potential cytostatic agents. The improvement of diagnostic techniques of fungal infections typical of oncological patients will be the additional goal of the project. DNA probes will be prepared for clinica diagnostics. (en)
- Projekt je směřován na zlepšení diagnostiky v onkologické praxi, a to jednak u primárního onemocnění a jednak u přidružených infekcí. Cílem projektu bude zejména vývoj cytometrických technik s vysokým rozlišením a metod detekce telomerazové aktivity. Budou měřeny topografické charakteristiky vhodných genetických oblastí ve vybraných nádorových tkáních a porovnávány s vlasnostmi nádoru. Na cílený výzkum v klinice bude navazovat průmyslový vývoj levného konfokálního cytometru. Metody detekce aktivity a exprese telomerázy ve vzorcích nádorových tkání budou optimalizovány jednak pro účely onkologické diagnostiky, jednak pro zjišťování citlivosti kultivovaných nádorových buněk k cytostatikům a potenciálním cytostatikům. Dalším cílem projektu bude zlepšení diagnostiky moderních metod molekulární biofyziky. Vedlejším produktem výzkumu budou DNA sondy pro diagnostiku maligních onemocnění.
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| Title
| - Development of new diagnostic techniques for oncology (en)
- Vývoj nových diagnostických technik pro onkologii
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - molecular diagnostics;cytometry;confocal microscopy;carcinogenesis;telomerase;mycoses (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...okUkonceniPodpory
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| http://linked.open...okZahajeniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...jektu+dodavatelem
| - Byly získány nové originální poznatky o vztahu prostorového uspořádání genomu buňky k jeho genové expresi, o změnách struktury a exprese v průběhu diferenciace buněk a maligní transformace a o mechanismech regulace délky telomer a aktivity telomerázy. (cs)
- New results on the relation between the genome arrangement and its expression, on changes of the structure during cell differentiation and malignant transformation and on mechanisms of the regulation of the telomere length and telomerase were obtained. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - confocal microscopy
- telomerase
- carcinogenesis
- cytometry
- molecular diagnostics
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| is http://linked.open...vavai/riv/projekt
of | - Rapid concerted evolution of nuclear ribosomal DNA in two tragopogon allopolyploids of recent and recurrent origin
- Molecular cytogenetics and tandem repeat sequence evolution in the allopolyploid Nicotiana rustica compared with diploid progenitors N. paniculata and N. undulata
- Interferon-gamma, but not interferon-alpha, induces SOCS 3 expression in human melanoma cell lines
- Different nuclear localization of aberrant and normal chromosome 8 homologues in intact or NaBt differentiated HT-29 cells
- Concerted evolution of 18-5.8-26S rDNA repeats in Nicotiana allotetraploids
- Different nuclear localization of aberrant and normal chromosome 8 homologues in intact of NaBt differentiated HT-29 cells
- From Jenalumar to ultrafast microscopy of living cells
- Methylation of histones in myeloid leukemias as a potential marker of granulocyte abnormalities
- Exchange aberrations among 11 chromosomes of human lymphocytes induced by gamma-rays.
- Location of centromeric heterochromatin in chromosomal domains during human blood cell differentiation.
- Cytogenetics and cytology of retinoblastomas
- Chromosomal territory segmentation in apoptotic cells
- Image analysis of the movement of sub-cellular structures
- Telomeres Analysis of Tumor Cells by in situ Techniques
- 3D Structure of the human genome: Order in randomness
- The 3D structure of human chromosomes in cell nuclei
- A network solution for high-resolution image cytometry
- Nuclear and territorial topography of chromosome telomeres in human lymphocytes
- 3D Object reconstructions in image cytometry
- Dynamic changes in the distribution of a satellite homologous to intergenic 26-18S rDNA spacer in the evolution of Nicotiana
- Dynamics of HP1 transgene loci movement and silencing in living cells
- Nuclear Topography and Gene Activity.
- Transposition of IS10 from the host Escherichia coli genome to a plasmid may lead to cloning artefacts.
- Algorithms and data representation in the FISH 3.0 image processing system
- Cytogenetics of Retinoblastoma
- Distribution of 5-methylcytosine residues in 5S rRNA genes in Arabidopsis thaliana and Secale cereale.
- High-resolution cytometry network project: Towards remote and distributed acquisition, processing and visualisation of 3D image data in human genome research
- FISH 3.0 client-server system for 3D optical microscope data storage and analysis
- Genomics in the ends - progress and perspectives of biology of telomeres.
- Optimisation of FISH Methodology for the Study of 3D Structure of Cell Nuclei Using Micro Axial Tomography
- Nuclear structure and gene activity in human differentiated cells
- The risk of chronic myeloid leukemia: Can the dose-response curve be U-shaped?
- Dual-color real-time telomeric repeat amplification protocol
- Telomerase Activity and Expression and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
- Spherical Object Reconstruction Using Star-Shaped Simplex Meshes
- Spatial Arrangement of Genetic Loci in Human Blood Cell Nuclei Studied by Confocal Cytometry.
- Spatial arrangement of genetic loci in human blood cell nuclei studied by confocal cytometry.
- Chromatin modifications determined in retinoblastoma
- Cell Nuclei Segmentation Using Star-Shaped Simplex Meshes
- Chromatin structure in solid cancers and leukemic cells.
- Effectivity of Spherical Object Reconstruction Using Star-Shaped Simplex Meshes
- An efficient algorithm for measurement and correction of chromatic aberrations in fluorescence microscopy
- Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differentiation and after irradiation
- Spatial arrangement of genes, centromeres and chromosomes in human blood cell nuclei and its changes during the cell cycle, differntiation and after irradiation.
- Combined confocal and wide-field high-resolution cytometry of FISH-stained cells
- Changes in the expression of FGFR3 in patients with chronic myeloid leukaemia receiving transplants of allogeneic peripheral blood stem cells
- Combined Confocal and Wide-Field High-Resolution Cytometry of Fluorescent In Situ Hybridization-Stained Cells.
- Spherical Object Reconstruction Using Simplex Meshes from Sparse Data
- Cytogenetics of Retinoblastoma.
- In Situ Analysis of Telomeres in Haematological Malignancies
- Evaluation of telomerase activity and telomere length in multiple myeloma
- Higher-order chromatin structure of human granulocytes.
- Induction of Chronic Myeloid Leukemia by Ionizing Radiation: Experimental Basis for Risk Estimation.
- Multilevel Adaptive Thresholding and Dual Simplex Mesh Deformation as a Tool for Tissue Reconstruction
- Tiptoeing to chromosome tips: facts, promises and perils of today's human telomere biology
- Structure of the human genome: Experimental results and models
- Topography of genetic elements of X-chromosome relative to the cell nucleus and to the chromosome X territory determined for human lymphocytes
- Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells
- Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI-1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells
- Architecture of chromosomal territories in apoptotic cells
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