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| Description
| - Novel modular methodologies for synthesis of new C-nucleosides will be developed based on cross-coupling reactions of haloaryl C-nucleosides and heterocyclications of alkynylsugars. The methodologies will be used in synthesis of large series of new C-nucleosides for biological activity screening and for applications chemical biology. Selected C-nucleosides will be incorporated to oligonucleotides and stability of DNA duplexes will be studied. Other selected examples will be converted to nucleoside triphosphates and used for studying of selectivity of incorporation by DNA polymerases. (en)
- Budou vyvíjeny nové modulární metodiky pro syntézu nových typů C-nukleosidů založené na cross-coupling reakcích halogenaryl C-nukleosidů a na heterocyklizacích alkynylcukrů. Metodiky budou využity pro syntézy velkých serií nových C-nukleosidů, u kterých bude studována biologická aktivita a které budou aplokovány v chemické biologii. Vybrané C-nukleosidy budou inkorporovány do oligonukleotidů a studována stabilita duplexů DNA. Od vybraných příkladů budou připraveny nukleosid trifosfáty a použity pro studium selektivity inkorporace DNA polymerasami.
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| Title
| - Development of modular syntheses of new C-nucleosides for studying DNA polymerase specificity and for the extension of the genetic alphabet (en)
- Vývoj modulárních syntézy nových C-nukleosidů pro studium specificity DNA polymeras a rozšíření genetické abecedy
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - C-nucleosides; nucleosides; DNA; cross-coupling reactions (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Byla vypracována obecná a modulární metodika syntézy C-ribo- a deoxyribonukleosidů odvozených od benzenu, pyridinu, pyrimidinu, furanu, thiofenu a pyrrolu pro využití ve studiích DNA polymeras a rozšíření genetické abecedy. Bylo publikována 17 prací. (cs)
- A new general and modular methodology for the synthesis of C-ribo- a deoxyribonucleosides derived from benzene, pyridine, pyrimidine, furan, thiofene a pyrrole for studying DNA polymerases and extension of the genetic alphabet. 17 papers were published. (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - C-nucleosides
- DNA
- nucleosides
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| is http://linked.open...vavai/riv/projekt
of | - Synthesis of benzamide C-ribonucleosides by Pd-catalyzed aminocarbonylations
- Herpes Simplex Virus-1 DNA Primase: A Remarkably Inaccurate yet Selective Polymerase
- C-Nucleosides: Synthetic Strategies and Biological Applications
- Mechanisms by Which Human DNA Primase Chooses To Polymerize a Nucleoside Triphosphate
- Sonogashira reactions of alpha and beta-1-ethynyl-2-deoxyribosides: synthesis of acetylene-extended C-nucleosides
- Synthesis of 2,4-Disubstituted Pyrimidin-5-yl C-2'-Deoxyribonucleosides by Sequential Regioselective Reactions of 2,4-Dichloropyrimidine Nucleosides
- Modular Synthesis of 5-Substituted Furan-2-yl C-2'-Deoxyribonucleosides and Biaryl Covalent Base-pair Analogues
- Synthesis of Phenol and Pyridone C-Ribo-and 2'-Deoxyribonucleosides by Palladium-Catalyzed Hydroxylations of Haloaryl C-Nucleosides
- B Family DNA Polymerases Asymmetrically Recognize Pyrimidines and Purines
- Furan-Oxidation-Triggered Inducible DNA Cross-Linking: Acyclic Versus Cyclic Furan-Containing Building Blocks-On the Benefit of Restoring the Cyclic Sugar Backbone
- General and Modular Synthesis of Isomeric 5-Substituted Pyridin-2-yl and 6-Substituted Pyridin-3-yl C-Ribonucleosides Bearing Diverse Alkyl, Aryl, Hetaryl, Amino, Carbamoyl, and Hydroxy Groups
- Modular synthesis of 1-.alpha.- and 1-.beta.-(indol-2-yl)-2´-deoxyribose C-nucleosides
- A General Regioselective Approach to 2,4-Disubstituted Pyrimidin-5-yl C-2-Deoxyribonucleosides
- A Modular Approach to Aryl-C-ribonucleosides via the Allylic Substitution and Ring-Closing Metathesis Sequence. A Stereocontrolled Synthesis of All Four alpha-/beta- and D-/L-C-Nucleoside Stereoisomers
- Synthesis of 6-Substituted 2(1H)-Pyridon-3-yl C-2'-Deoxyribonucleosides
- Synthesis of Substituted Benzyl Homo-C-Ribonucleosides and -Nucleotides as Carba-Analogues of Phosphoribosylanthranilate
- A General and Efficient Synthesis of Pyridin-2-yl C-Ribonucleosides Bearing Diverse Alkyl, Aryl, Amino and Carbamoyl Groups in Position 6
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| is http://linked.open...vavai/cep/projekt
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