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  • All of the evidence from animal and human studies showed that there are risks associated with inhalation of nano-sized particles (NSP). The alveolar translocation of NSP is likely the pathway how NSP can be transposed from air to the blood vessels, and distributed throughout the body to organs. In spite of the fact that an extrapulmonary translocation is highly dependent on particle surface characteristics/chemistry, in addition to particle size, the study of transport of inhalated nano-particles Pb, Cd (elements, oxides), their allocations in organs, as well as study of toxicity these nanoparticles will be carry out with nanoparticles (10, 20 and 60 nm).       The nonbiogenous elements (Cd, Pb) have been selected as products of technological processes and due to their presence in ambient aerosol. The research will give us more information for a proper understanding of risks of technologies producing Cd and Pb nano-sized particles and ambient aerosol risk.  (en)
  • Existuje reálný a nevyřešený problém spojený s inhalací aerosolů, které mají charakter nanočástic. Při inhalaci jsou tyto miniaturní objekty transportovány do krevního řečiště a dále do jednotlivých orgánů, v nichž se mohou ukládat. Účinnost transportu závisí vedle velikosti částic také na jejich chemických a povrchových vlastnostech. V projektu se zaměríme na studium transportu a akumulace nanočástic (10-60 nm), které jsou složené z prvků nebo oxidů (Cd, Pb) nemajících biogenní charakter v tělech inhalačně exponovaných myší. Nanočástice Pb a Cd (prvky, oxidy) jsou produkovány při různých technolgických procesech a patří k významný polutantům životního prostředí.
Title
  • Study of transport of inhalated nano-sized particles (Pb, Cd) and their allocation in organs (en)
  • Studium transportu inhalovaných nanočástic (Pb, Cd) a jejich lokalizace v orgánech
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  • GAP503/11/2315
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  • inhalated nano-sized particles allocation organs (en)
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