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| Description
| - Stem cells (SC) are a promising tool, which could allow tissue regeneration. Regardless of their localization in various tissues in human organism SC have unique abilities of proliferation, differentiation an plasticity. The aim of proposed project is to characterize three different types of SC isolated from adult tissues (mesenchymal SC from bone marrow, dental pulp SC, and periodontal ligament SC) and compare their resistance to genotoxic stress (ionizing radiation, cytostatics). While hematopoietic SC die after DNA damage by apoptosis, some studies suggest that mesenchymal SC do not react to irradiation by apoptosis, not even after high doses, but only lose their ability to proliferate. This response allows for selection of resistant population, but has a significant downside as it creates a risk of developing a population of cells with damaged genome, if the cells survive in spite of an imperfect DNA repair. We want to study morphological changes after exposure of SC to genotoxic stressors; repair processes, cell cycle regulation, apoptosis, and senescence on molecular level. (en)
- Cílem projektu je doplnit charakteristiku tří typů kmenových buněk (KB) (kostní dřeně, zubní pulpy a periodontálního ligamenta), a to o vyšetření jejich odolnosti vůči genotoxickým stresorům. Budeme studovat morfologické změny, reparační pochody, regulaci buněčného cyklu, apoptózy a senescence.
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| Title
| - Chatacteristic of resistance of adult stem cells to genotoxic stress (en)
- Charakteristika odolnosti dospělých kmenových buněk vůči genotoxickému stresu
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - kmenová buňka; poškození DNA; genotoxický stres; senescence; apoptóza; p53; p21; p16 (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open.../cep/vedlejsiObor
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - The project gone according to plan both in terms of expertise and in terms of disbursement of funds. (en)
- Řešení projektu proběhlo podle plánu jak z hlediska odborného tak i z hlediska čerpání finančních prostředků. (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - apoptóza
- genotoxický stres
- p21
- p53
- poškození DNA
- senescence
- kmenová buňka
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| is http://linked.open...vavai/riv/projekt
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| is http://linked.open...vavai/cep/projekt
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