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| Description
| - The project is focused on synthesis and study of new ligands and their complexes with lanthanides and transition metals with aim to participate on the international research and development of new contrast agents for Magnetic Resonance Imaging Synthesis of new ligands derived from tetraazacycles bearing acetate, methylphosphonate or phosphinate, eventually, other pendants would be the main part of the project. Through the pendant groups, additional functionalities able to anchor biomolecules or to change relaxivity in dependence on pH, concentration of calcium etc., will be bond to the ligands. In addition to preparation of the model complexes and determination of their structure by x-ray diffraction methods, research will be directed to the solution studies. Thermodynamic (stability constants, isomerism) as well as kinetic (formation and dissociation rates of complexes, water exchange rate etc.) properties of the complexes will be investigated on the parent compounds. It makes possible to (en)
- Projekt je zaměřen na syntézu a studium nových ligandů a jejich komplexů s lanthanoidy a s přechodnými kovy s cílem se podílet na mezinárodním výzkumu a vývoji nových kontrastních látek pro tomografii NMR. Hlavní součástí by měla býti syntéza nových ligandů odvozených od tetraazacyklů nesoucích acetátové, methylfosfonátové nebo fosfinátové, případně další pendantní skupiny. Prostřednictvím pendantních skupin budou k ligandům připojeny další funkční skupiny schopné se vázat na nosič a také na biomolekuly případně měnit relaxivitu gadolinitých komplexů se změnou pH, koncentrací vápníku atp. Vedle přípravy modelových sloučenin a určení jejich struktury metodami RTG difrakce, bude pozornost soustředěna na roztokové studie. Termodynamické (konstanty stability, isomerizace) i kinetické (rychlosti tvorby a disociace komplexů, rychlost výměny vody atd.) vlastnosti budou zkoumány na vybraných komplexech jednodušších ligandů. To umožní získat více poznatků o vztahu mezi strukturou a
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| Title
| - Chelates and their complexes for biomedical aplications (en)
- Cheláty a jejich komplexy pro biomedicinské aplikace
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - magnetic resonance imaging; NMR spectroscopy; molecular imaging; lanthanides (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Grant byl převážně zaměřen na studium kontrastních látek (CA) pro magnetickou resonanci (MRI), které jsou založeny na gadolinitých komplexech. Hlavním cílem bylo porozumění vztahům mezi strukturou komplexů a jejich relaxivitou, což je veličina, která vyj (cs)
- The grant was mostly oriented on investigation of contrast agents (CA) for Magnetic Resonance Imaging (MRI) based on gadolinium(III) complexes. The main goal was understanding of relation between structure of the complexes and their relaxivity that expre (en)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - magnetic resonance imaging
- NMR spectroscopy
- molecular imaging
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| is http://linked.open...vavai/riv/projekt
of | - Complexation and biodistribution study of (111)In and (90)Y complexes of bifunctional phosphinic acid analogs of H(4)dota
- Lanthanide(III) Complexes of Phosphorus Acid Analogues of H(4)DOTA as Model Compounds for the Evaluation of the Second-Sphere Hydration
- Pyridine-N-oxide Analogues of DOTA and Their Gadolinium(III) Complexes Endowed with a Fast Water Exchange on the Square-Antiprismatic Isomer
- Lanthanide(III) Complexes of Pyridine-N-Oxide Analogues of DOTA in Solution and in the Solid State. A Near Kind of Isomerism in Complexes of DOTA-like Ligands
- Aminoalkylbis(phosphonates): Their complexation properties in solution and in the solid state
- Gadolinium(III) complexes of mono- and diethyl esters of monophosphonic acid analogue of DOTA as potential MRI contrast agents: solution structures and relaxometric studies
- Preparation and structural characterization of the intermediate complex [Er{H2C8H16N4(CH2COO)(3) (CH2(Ph)PO2)}(H2O)(2)](2)Cl-2 center dot xH(2)O in the reaction of Er3+ and the dota-type ligand. An interesting example of two stereoforms of a lanthanide
- Relaxometric and solution NMR structural studies on ditopic lanthanide(III) complexes of a phosphinate analogue of DOTA with a fast rate of water exchange
- Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: an O-17 and H-1 relaxation study of its Gd(III) complex
- PAMAM dendrimeric conjugates with a Gd-DOTA phosphinate derivative and their adducts with polyaminoacids: The interplay of global motion, internal rotation, and fast water exchange
- Coordination properties of cyclam (1,4,8,11-tetraazacyclotetradecane) endowed with two methylphosphonic acid pendant arms in the 1,4-positions
- Gadolinium(III) complexes as MRI contrast agents: ligand design and properties of the complexes
- Synthesis of a bifunctional monophosphinate DOTA derivative having a free carboxylate group in the phosphorus side chain
- Unsymmetrically substituted side-bridged cyclam derivatives and their Cu(II) and Zn(II) complexes
- HPLC separace polykarboxylátových derivátů cyklenu s využitím bezkontaktní vodivostní detekce
- Complexes of DOTA-bisphosphonate conjugates: Probes for determination of adsorption capacity and affinity constants of hydroxyapatite
- Capillary Electrophoretic Separation and Kinetic Study of Inert Copper(II) Complexes of 1,8-bis(methylphosphonate) Derivative of Cyclam
- Thermodynamic, kinetic and solid-state study of divalent metal complexes of 1,4,8,11-tetraazacyclotetradecane (cyclam) bearing two trans (1,8-)methylphosphonic acid pendant arms
- Thermodynamic study of lanthanide(III) complexes with bifunctional monophosphinic acid analogues of H4dota and comparative kinetic study of yttrium(III) complexes
- Three in one: TSA, TSA ', and SA units in one crystal structure of a yttrium(III) gornplex with a monophosphinated H-4 dota analogue
- Selective protection of 1,4,8,11-tetraazacyclotetradecane (cyclam) in position 1,4 with the phosphonothioyl group and synthesis of a cyclam-1,4-bis(methylphosphonic acid). Crystal structures of several cyclic phosphonothioamides
- Study of thermodynamic and kinetic stability of transition metal and lanthanide complexes of DTPA analogues with a phosphorus acid pendant arm
- Synthesis and coordination Behavior of symmetrical tetraamine phosphinic acids
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| is http://linked.open...vavai/cep/projekt
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