About: Morphine Sulfate Sustained-Release Tablet

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Attributes	Values
rdf:type	Class
rdfs:label	Morphine Sulfate Sustained-Release Tablet
rdfs:subClassOf	Opioid Agonist
Semantic_Type	Pharmacologic Substance
Preferred_Name	Morphine Sulfate Sustained-Release Tablet
NCI_META_CUI	CL412993
PDQ_Open_Trial_Search_ID	651246
PDQ_Closed_Trial_Search_ID	651246
FULL_SYN	Morphine Sulfate Sustained-Release TabletPTNCI
DEFINITION	A sustained-release tablet formulation containing the sulfate salt of the opiate alkaloid morphine with analgesic activity. Morphine binds to and activates the mu-opioid receptors in the central nervous system (CNS), thereby mimicking the effects of the endogenous opioids. Binding of morphine to opioid receptors stimulates exchange of GTP for GDP, inhibits adenylate cyclase, and decreases intracellular cAMP. This inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, morphine closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels, which results in hyperpolarization of neuronal membranes and a reduction in neuronal excitability, and subsequently, analgesia and sedation.NCI
code	C84853

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