About: Avasimibe     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Avasimibe
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Avasimibe
UMLS_CUI
  • C0965226
CAS_Registry
  • 166518-60-1
FDA_UNII_Code
  • 28LQ20T5RC
Contributing_Source
  • FDA
Chemical_Formula
  • C29H43NO4S
Legacy_Concept_Name
  • Avasimibe
FULL_SYN
  • AVASIMIBEPTFDA28LQ20T5RC
  • AvasimibePTNCI
DEFINITION
  • An orally bioavailable inhibitor of acyl-Coenzyme A:cholesterol acyltransferase (ACAT) that prevents cholesterol deposition in the arterial wall. Research was discontinued due to difficulties in assaying the effects of avasimibe on preventing plaque formation and due to its ability to increase the activity of Cytochrome P450 3A4, thus increasing the removal of other drugs from the body.NCI
code
  • C75252
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