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AttributesValues
rdf:type
rdfs:label
  • Argatroban Anhydrous
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Argatroban Anhydrous
UMLS_CUI
  • C2698183
CAS_Registry
  • 74863-84-6
FDA_UNII_Code
  • OCY3U280Y3
Contributing_Source
  • FDA
Legacy_Concept_Name
  • Argatroban_Anhydrous
FULL_SYN
  • ARGATROBAN ANHYDROUSPTFDAOCY3U280Y3
  • Argatroban AnhydrousPTNCI
DEFINITION
  • The anhydrous form of argatroban, a synthetic derivative of L-arginine with antithrombotic activity. Argatroban is a univalent and direct inhibitor of fibrin-bound thrombin. This agent reversibly binds to the thrombin active site, thereby preventing the thrombin-dependent reactions, which include the conversion of fibrinogen to fibrin; the activation of factors V, VIII and XI; the activation of protein C; and platelet aggregation. Argatroban is highly selective for thrombin and is able to inhibit the action of both free and clot-associated thrombin. As a result, stabilization of blood clots occurs and coagulation is inhibited.NCI
code
  • C75153
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