About: Naloxone Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Naloxone Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Naloxone Hydrochloride
NSC_Code
  • 70413
UMLS_CUI
  • C0684237
CAS_Registry
  • 357-08-4
FDA_UNII_Code
  • F850569PQR
Contributing_Source
  • FDA
ALT_DEFINITION
  • A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39509
PDQ_Closed_Trial_Search_ID
  • 39509
Chemical_Formula
  • C19H21NO4.HCl
Legacy_Concept_Name
  • Naloxone
FULL_SYN
  • Naloxone HydrochloridePTNCI
  • NALOXONE HYDROCHLORIDEPTFDAF850569PQR
  • NarcanSYDTPNSC0070413
  • NarcanBRNCI
DEFINITION
  • The hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity. Naloxone binds to opioid receptors in the CNS in a competitive manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. This agent binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors.NCI
code
  • C678
sameAs
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