About: Mafenide Acetate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mafenide Acetate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Mafenide Acetate
NSC_Code
  • 34632
UMLS_CUI
  • C0809894
CAS_Registry
  • 13009-99-9
FDA_UNII_Code
  • RQ6LP6Z0WY
Contributing_Source
  • FDA
Chemical_Formula
  • C7H10N2O2S.C2H4O2
Legacy_Concept_Name
  • Mafenide_Acetate
FULL_SYN
  • alpha-Amino-p-toluenesulfonamide MonoacetateSYNCI
  • 4-(Aminomethyl)benzenesulfonamide MonoacetateSNNCI
  • MAFENIDE ACETATEPTFDARQ6LP6Z0WY
  • Mafenide AcetatePTNCI
  • SulfamilonSYNCI
  • SulfamylonBRNCI
DEFINITION
  • The acetate salt form of mafenide, a synthetic sulfonamide analog of para-aminobenzoic acid (PABA) with topical anti-infective activity. Mafenide acetate competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, thereby interferes with normal folic acid metabolism. As a result, de novo synthesis of pyrimidines, which requires folate metabolites, is impeded and subsequently DNA synthesis is affected. Mafenide acetate is bacteriostatic against many gram-negative and gram-positive organisms, including Pseudomonas aeruginosa and certain strains of anaerobes.NCI
code
  • C47591
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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