About: Isosorbide Mononitrate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Isosorbide Mononitrate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Isosorbide Mononitrate
UMLS_CUI
  • C0064079
CAS_Registry
  • 16051-77-7
FDA_UNII_Code
  • LX1OH63030
Contributing_Source
  • FDA
Chemical_Formula
  • C6H9NO6
Legacy_Concept_Name
  • Isosorbide_Mononitrate
CHEBI_ID
  • CHEBI:6062
FULL_SYN
  • Isosorbide MononitratePTNCI
  • ISOSORBIDE MONONITRATEPTFDALX1OH63030
  • ISMOBRNCI
  • 1,4:3,6-Dianhydro-D-glucitol 5-nitrateSNNCI
  • ImdurBRNCI
  • MonoketBRNCI
  • MonosordilSYNCI
DEFINITION
  • The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)NCI
code
  • C47575
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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