About: MAPK Signaling Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: MAPK Signaling Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	MAPK Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	MAPK Signaling Pathway
UMLS_CUI	C1518102
KEGG_ID	hsa04010
ALT_DEFINITION	The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.KEGG
Legacy_Concept_Name	MAPK_Signaling_Pathway
FULL_SYN	MAPK Signaling PathwayPTNCI MAPK Signaling PathwayPTKEGG
code	C38834
is someValuesFrom of	nodeID://b641821 nodeID://b642354 nodeID://b642434 nodeID://b642473 nodeID://b647987 nodeID://b649117 nodeID://b652474 nodeID://b654901 nodeID://b654932 nodeID://b654966 nodeID://b654998 nodeID://b657888 nodeID://b664807 nodeID://b664827 nodeID://b664857 nodeID://b665043 nodeID://b665450 nodeID://b665871 nodeID://b665882 nodeID://b667790 nodeID://b667815 nodeID://b667825 nodeID://b667833 nodeID://b668580 nodeID://b668623 nodeID://b668812 nodeID://b668856 nodeID://b668885 nodeID://b669503 nodeID://b669632 nodeID://b669804 nodeID://b669844 nodeID://b670433 nodeID://b670484 nodeID://b672110 nodeID://b672606 nodeID://b672676 nodeID://b673408 nodeID://b675646 nodeID://b677695 nodeID://b679019 nodeID://b679033 nodeID://b679057 nodeID://b679255 nodeID://b679275 nodeID://b681310 nodeID://b682678 nodeID://b684603 nodeID://b684614 nodeID://b684683 nodeID://b684775 nodeID://b688131 nodeID://b688156 nodeID://b688180 nodeID://b688208 nodeID://b688245 nodeID://b688335 nodeID://b688391 nodeID://b688401 nodeID://b688416 nodeID://b688460 nodeID://b688499 nodeID://b688597 nodeID://b688682 nodeID://b688741 nodeID://b688772 nodeID://b688782 nodeID://b688800 nodeID://b688829 nodeID://b688908 nodeID://b688929 nodeID://b688951 nodeID://b688974 nodeID://b689008 nodeID://b689089 nodeID://b689191 nodeID://b689243 nodeID://b689250 nodeID://b689259 nodeID://b689304 nodeID://b689343 nodeID://b689464 nodeID://b689676 nodeID://b690737 nodeID://b690776 nodeID://b690783 nodeID://b691048 nodeID://b691062

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 46 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software