About: BH3-Interacting Domain Death Agonist     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • BH3-Interacting Domain Death Agonist
equivalentClass
OMIM_Number
  • 601997
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • BH3-Interacting Domain Death Agonist
UMLS_CUI
  • C0531588
Legacy_Concept_Name
  • BH3_Interacting_Domain_Death_Agonist_Protein
FULL_SYN
  • BH3 Interacting Domain Death AgonistSYNCI
  • BH3-Interacting Domain Death AgonistPTNCI
  • BIDSYNCI
  • p22 BIDSYNCI
Swiss_Prot
  • P55957
DEFINITION
  • BH3-interacting domain death agonist (195 aa, ~22 kDa) is encoded by the human BID gene. This protein plays a role in the promotion of apoptosis.NCI
DesignNote
  • BID (BH3 Interacting domain Death agonist) is a death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL2). BID is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. (from RefSeq Summary)
  • Tumor necrosis factor-alpha induces a caspase-mediated cleavage of p22 BH3-interacting domain death agonist into a major p15 and minor p13 and p11 products. Once cleaved, the products become associated with the mitochondrial membrane. (UniProt)
  • BH3-interacting domain death agonist has 4 isoforms, 3 of them are able to induce apoptosis, through sequestration of anti-apoptotic factors.
code
  • C21199
sameAs
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