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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pipendoxifene
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pipendoxifene
UMLS_CUI
  • C0935699
CAS_Registry
  • 198480-55-6
In_Clinical_Trial_For
  • Breast cancer
FDA_UNII_Code
  • TPC5Q8496G
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied as a treatment for cancer. It belongs to a family of drugs called antiestrogens.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38112
PDQ_Closed_Trial_Search_ID
  • 38112
Chemical_Formula
  • C29H32N2O3
Legacy_Concept_Name
  • ERA_923
FULL_SYN
  • PIPENDOXIFENEPTFDATPC5Q8496G
  • PipendoxifenePTNCI
  • ERA-923PTNCI-GLOSSCDR0000044982
  • ERA 923CNNCI
  • ERA-923PTDCP50472
  • 2-(4-Hydroxyphenyl)-3-methyl-1-[4-(2-piperidin-1-ylethoxy)benzyl]-1H-indol-5-ol HydrochlorideSNNCI
DEFINITION
  • A nonsteroidal 2-phenyl indole and a selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Pipendoxifene antagonizes binding of estradiol to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated gene expression, interfering with estrogen activity and inhibiting estrogen-stimulated growth in estrogen-dependent breast cancer. In addition, this agent also exerts intrinsic estrogenic activity depending on the tissue types.NCI
code
  • C1874
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