About: Capecitabine

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Capecitabine Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Capecitabine
rdfs:subClassOf	Pyrimidine Antagonist
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Capecitabine
NSC_Code	712807
UMLS_CUI	C0671970
CAS_Registry	154361-50-9
Accepted_Therapeutic_Use_For	Breast cancer; Colorectal cancer, Stage III colon cancer
In_Clinical_Trial_For	Biliary tract cancer; breast cancer; cervical cancer; colorectal cancer; gastric cancer; gastrointestinal junction adenocarcinoma; hepatocellular carcinoma; liver metastases; pancreatic cancer; renal cell cancer; unspecified solid tumors
FDA_UNII_Code	6804DJ8Z9U
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat stage III colon cancer in patients who had surgery to remove the cancer. It is also used to treat metastatic breast cancer that has not improved after treatment with certain other anticancer drugs. Xeloda is being studied in the treatment of other types of cancer. It is taken up by cancer cells and breaks down into 5-fluorouracil, a substance that kills tumor cells. Xeloda is a type of antimetabolite.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42852
PDQ_Closed_Trial_Search_ID	42852
Chemical_Formula	C15H22FN3O6
Legacy_Concept_Name	Capecitabine
CHEBI_ID	CHEBI:31348
FULL_SYN	CapecitabinePTNCI Ro 09-1978/000CNNCI capecitabinePTNCI-GLOSSCDR0000045565 CapecitabinePTDCP50091 XelodaPTNCI-GLOSSCDR0000508532 XelodaBRNCI 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidineSNNCI CAPECITABINEPTFDA6804DJ8Z9U
DEFINITION	A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. (NCI04)NCI
code	C1794
sameAs	CAPECITABINE CAPECITABINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0287377
is someValuesFrom of	nodeID://b644475 nodeID://b650297 nodeID://b650300 nodeID://b652358 nodeID://b652363 nodeID://b656609 nodeID://b656612 nodeID://b656613 nodeID://b656617 nodeID://b656621 nodeID://b656624 nodeID://b656625 nodeID://b656627 nodeID://b656630 nodeID://b656632 nodeID://b656636 nodeID://b656639 nodeID://b656641 nodeID://b656643 nodeID://b656646 nodeID://b656647 nodeID://b656649 nodeID://b656652 nodeID://b656655 nodeID://b656657 nodeID://b656658 nodeID://b675090 nodeID://b675880 nodeID://b723755
is sameAs of	CAPECITABINE CAPECITABINE CAPECITABINE

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 46 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software