About: Gamma-Glutamylcysteine Synthetase     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Gamma-Glutamylcysteine Synthetase
rdfs:subClassOf
Semantic_Type
  • Enzyme
Preferred_Name
  • Gamma-Glutamylcysteine Synthetase
UMLS_CUI
  • C0017037
ALT_DEFINITION
  • One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.MSH2001
Legacy_Concept_Name
  • Gamma-Glutamylcysteine_Synthetase
FULL_SYN
  • Gamma-Glutamylcysteine SynthetasePTNCI
  • Gamma-Glutamylcysteinyl SynthetaseSYNCI
  • Glutamate-Cysteine LigaseSYNCI
  • EC 6.3.2.2SYNCI
DEFINITION
  • Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. (LocusLink)NCI
code
  • C16602
sameAs
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