About: Arsenic Trioxide

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Arsenic Trioxide
equivalentClass	nodeID://b629722
Has_Target	PML/RARA Fusion Protein
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Inorganic Chemical Pharmacologic Substance
Preferred_Name	Arsenic Trioxide
NSC_Code	706363
UMLS_CUI	C0052416
CAS_Registry	1327-53-3
Accepted_Therapeutic_Use_For	Myelodysplastic syndrome; multiple myeloma; chronic myeloid leukemia; acute myelocytic leukemia
In_Clinical_Trial_For	Refractory leukemia or lymphoma; resistant chronic phase chronic myelogenous leukemia; acute promyelocytic leukemia; recurrent or refractory multiple myeloma; locally advanced or metastatic non-small cell lung cancer Locally advanced or metastatic breast cancer; refractory testicular or extragonadal germ cell malignancies; refractory adenocarcinoma of the pancreas; advanced adenocarcinoma of the esophagus or gastroesophageal junction Advanced neuroblastoma or other pediatric solid tumors; metastatic stage IVA or IVB hormone-refractory prostate cancer; myelodysplastic syndromes
FDA_UNII_Code	S7V92P67HO
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat acute promyelocytic leukemia (APL) that has not gotten better or that has come back after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43067
PDQ_Closed_Trial_Search_ID	43067
Chemical_Formula	As2O3
Legacy_Concept_Name	Arsenic_Trioxide
CHEBI_ID	CHEBI:30621
FULL_SYN	Arsenous Acid AnhydrideSYNCI Arsenous AcidSYNCI White ArsenicSYNCI Arsenous OxideSYNCI ARSENIC TRIOXIDEPTFDAS7V92P67HO Arsenic TrioxidePTNCI Arsenic (III) OxideSYNCI Arsenic SesquioxideSYNCI TrisenoxPTNCI-GLOSSCDR0000523452 TrisenoxBRNCI arsenic trioxidePTNCI-GLOSSCDR0000046018
DEFINITION	A small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic. (NCI04)NCI
code	C1005
sameAs	ARSENIC TRIOXIDE ARSENIC TRIOXIDE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0049263
is someValuesFrom of	nodeID://b646657 nodeID://b646660 nodeID://b646661 nodeID://b646663
is sameAs of	ARSENIC TRIOXIDE ARSENIC TRIOXIDE ARSENIC TRIOXIDE

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