About: Ioflupane I 123

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About: Ioflupane I 123 Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5736-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Tolosa E, Borght TV, Moreno E: Accuracy of DaTSCAN (123I-Ioflupane) SPECT in diagnosis of patients with clinically uncertain parkinsonism: 2-year follow-up of an open-label study. Mov Disord. 2007 Dec;22(16):2346-51. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17914722 # Benamer TS, Patterson J, Grosset DG, Booij J, de Bruin K, van Royen E, Speelman JD, Horstink MH, Sips HJ, Dierckx RA, Versijpt J, Decoo D, Van Der Linden C, Hadley DM, Doder M, Lees AJ, Costa DC, Gacinovic S, Oertel WH, Pogarell O, Hoeffken H, Joseph K, Tatsch K, Schwarz J, Ries V: Accurate differentiation of parkinsonism and essential tremor using visual assessment of [123I]-FP-CIT SPECT imaging: the [123I]-FP-CIT study group. Mov Disord. 2000 May;15(3):503-10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10830416 # http://md.gehealthcare.com/files/pdfs/msds/datscan.pdf (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Half life is 13.2 hours. (en)
http://linked.open...ugbank/indication	Ioflupane I-123 is a SPECT (single photon emission computerized tomography) agent used to distinguish between Parkinson’s syndrome tremors and essential tremor. (en)
sameAs	Ioflupane I 123
Title	Ioflupane I 123 (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB08824/identifier/chebi/68855 http://linked.opendata.cz/resource/drugbank/drug/DB08824/identifier/drugbank/DB08824 http://linked.opendata.cz/resource/drugbank/drug/DB08824/identifier/kegg-drug/D10014 http://linked.opendata.cz/resource/drugbank/drug/DB08824/identifier/national-drug-code-directory/17156-210-01 http://linked.opendata.cz/resource/drugbank/drug/DB08824/identifier/wikipedia/Ioflupane
http://linked.open...mechanismOfAction	Iodine-123 labeled ioflupane binds to presynaptic dopamine transporters. When Iodine-123 decays, a gammay ray is emmitted and detected through SPECT. (en)
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5310912
http://linked.open...outeOfElimination	About 60% is excreted in the urine and 14% in the feces after 48 hours. (en)
http://linked.open.../drugbank/synonym	123I-FP-CIT (en) 123I-Ioflupane (en) Methyl 8-(3-fluoropropyl)-3β-(p-iodo-I(sup 123)-phenyl)-1αH, 5αH-nortropane-2β-carboxylate. (en) Datscan (en) Ioflupane (en) methyl (1R,2S,3S,5S)-8-(3-fluoropropyl)-3-[4-((123)I)iodophenyl]-8-azabicyclo[3.2.1]octane-2-carboxylate (en) ioflupane ((123)I) (en) ioflupane (123I) (en) ioflupane I(123) (en) ioflupano (123I) (en) ioflupanum (123I) (en)
http://linked.open...umeOfDistribution	Compared to the entire brain, about 30% of radioactivity is taken up by the striatum. (en)
http://linked.open...k/foodInteraction	No known food interactions. (en)
foaf:page	http://www.drugs.com/mtm/ioflupane-i-123.html http://www.pdrhealth.com/info/v1us/ioflupane
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http://linked.open...ugbank/absorption	Absorption is 100% because administered I.V. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	155798-07-5 (en)
http://linked.open...drugbank/category	(en)
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http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5749-363D-11E5-9242-09173F13E4C5

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