About: Porfimer     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 10-452 hours (en)
http://linked.open...ugbank/indication
  • Indicated in the treatment of esophageal cancer. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Porfimer (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Cellular damage caused by porfimer is a consequence of the propagation of radical reactions. Radical initiation may occur after porfimer absorbs light to form a porphyrin excited state. Spin transfer from porfimer to molecular oxygen may then generate singlet oxygen. Subsequent radical reactions can form superoxide and hydroxyl radicals. Tumor death also occurs through ischemic necrosis secondary to vascular occlusion that appears to be partly mediated by thromboxane A2 release. (en)
http://linked.open...drugbank/packager
http://linked.open...y/drugbank/patent
http://linked.open.../drugbank/synonym
  • Dihematoporphyrin ether (en)
  • Dihaematoporphyrin Ether (en)
  • Photofrin II (en)
  • Porfimer natrium (en)
  • Porfimer sodico (en)
  • Porfimerum natricum (en)
  • Porfimère sodique (en)
http://linked.open...umeOfDistribution
  • * 0.49 ± 0.28 L/kg [2 mg/kg dose of porfimer sodium to 4 male cancer patients] (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...nk/proteinBinding
  • ~90% (en)
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...y/mesh/hasConcept
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...ogy/drugbank/logP
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 87806-31-3 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...rugbank/clearance
  • * Renal cl=199.7 +/-  56.9 mL/min [Healthy subjects receiving a single 300-mg oral dose] (en)
http://linked.open...gbank/containedIn
http://linked.open...tional-IUPAC-Name
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