About: Tamsulosin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4A31-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4A32-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Dunn CJ, Matheson A, Faulds DM: Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms. Drugs Aging. 2002;19(2):135-61. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11950378 # Lyseng-Williamson KA, Jarvis B, Wagstaff AJ: Tamsulosin: an update of its role in the management of lower urinary tract symptoms. Drugs. 2002;62(1):135-67. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11790159 # Wilt TJ, Mac Donald R, Rutks I: Tamsulosin for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2003;(1):CD002081. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12535426 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	5-7 hours (en)
http://linked.open...ugbank/indication	Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream...etc.) (en)
http://linked.open...bank/manufacturer	Breckenridge Pharmaceuticals Boehringer ingelheim pharmaceuticals inc Impax laboratories inc Mylan pharmaceuticals inc Sandoz inc Sun pharmaceutical industries ltd Apotheca Inc. Central Texas Community Health Centers Dispensing Solutions
sameAs	Tamsulosin Tamsulosin
Title	Tamsulosin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/chebi/9398 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/chemspider/114457 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/drugbank/DB00706 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/guide-to-pharmacology/488 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/iuphar/488 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/kegg-compound/C07124 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/national-drug-code-directory/0597-0058-01 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/pubchem-compound/129211 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/pubchem-substance/46507763 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/pharmgkb/PA451583 http://linked.opendata.cz/resource/drugbank/drug/DB00706/identifier/wikipedia/Tamsulosin
http://linked.open...mechanismOfAction	Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men. (en)
http://linked.open...drugbank/packager	A-S Medication Solutions LLC Sandoz GlaxoSmithKline Inc. Global Pharmaceuticals Kaiser Foundation Hospital Major Pharmaceuticals Mylan Pharmacy Service Center Physicians Total Care Inc. Preferred Pharmaceuticals Inc. Prepackage Specialists Prepak Systems Inc. Redpharm Drug Resource Optimization and Innovation LLC Sandoz Stat Rx Usa Synthon Pharmaceuticals Inc. Teva Pharmaceutical Industries Ltd. UDL Laboratories Vangard Labs Inc. Wockhardt Ltd. Zydus Pharmaceuticals Actavis Group AQ Pharmaceuticals Inc. Atlantic Biologicals Corporation Boehringer Ingelheim Ltd. Bryant Ranch Prepack Cadila Healthcare Ltd. Cardinal Health Diversified Healthcare Services Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2144077 http://linked.opendata.cz/resource/drugbank/patent/2490299 http://linked.opendata.cz/resource/drugbank/patent/4703063
http://linked.open...outeOfElimination	Tamsulosin hydrochloride is extensively metabolized by cytochrome P450 enzymes in the liver and less than 10% of the dose is excreted in urine unchanged. The metabolites of tamsulosin hydrochloride undergo extensive conjugation to glucuronide or sulfate prior to renal excretion. On administration of the radiolabeled dose of tamsulosin hydrochloride to four healthy volunteers, 97% of the administered radioactivity was recovered, with urine (76%) representing the primary route of excretion compared to feces (21%) over 168 hours. (en)
http://linked.open.../drugbank/synonym	Tamsulosin (en) Tamsulosina (en) Tamsulosine (en) Tamsulosinum (en) 5-[2-[2-(2-Ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide (en) (R)-5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub> = 650 mg/kg (in rats) (en)
http://linked.open...umeOfDistribution	* 16 L [intravenous administration to ten healthy male adults] (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/92-00-00
http://linked.open...k/foodInteraction	Take 30 minutes after a meal (always after the same meal). Taking the drug with food minimizes plasma levels variations. (en)
http://linked.open.../drugbank/mixture	JALYN Tamcontin-D Kaban
http://linked.open...nk/proteinBinding	94%-99% (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Hun Wang, Jun Park, Min Kwon, Ji Shim, Bong Lee, Hong Jeon, "Controlled release formulation of tamsulosin hydrochloride and preparation process thereof." U.S. Patent US20050100606, issued May 12, 2005. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0234193
foaf:page	http://www.drugs.com/cdi/tamsulosin.html http://www.rxlist.com/cgi/generic2/tamsul.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4A37-363D-11E5-9242-09173F13E4C5
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http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4A3C-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4A39-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4A3A-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B4A3B-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B4A35-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4A4D-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B4A33-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4A36-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4A4F-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B4A34-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Tamsulosin
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4A43-363D-11E5-9242-09173F13E4C5

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