| http://linked.open...generalReferences
| - # Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C: Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006 Jun 3;332(7553):1302-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16740558 # Solomon DH, Avorn J, Sturmer T, Glynn RJ, Mogun H, Schneeweiss S: Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk. Arthritis Rheum. 2006 May;54(5):1378-89. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16645966 # FitzGerald GA, Patrono C: The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med. 2001 Aug 9;345(6):433-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11496855 # Graham DJ: COX-2 inhibitors, other NSAIDs, and cardiovascular risk: the seduction of common sense. JAMA. 2006 Oct 4;296(13):1653-6. Epub 2006 Sep 12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16968830 # Brater DC: Renal effects of cyclooxygyenase-2-selective inhibitors. J Pain Symptom Manage. 2002 Apr;23(4 Suppl):S15-20; discussion S21-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11992745 # Sigma Aldrich "Link":http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIGMA/D6899 # Gan TJ: Diclofenac: an update on its mechanism of action and safety profile. Curr Med Res Opin. 2010 Jul;26(7):1715-31. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20470236 (en)
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| http://linked.open...mechanismOfAction
| - The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation. (en)
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