About: Foscarnet

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3F72-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	3.3-6.8 hours (en)
http://linked.open...ugbank/indication	For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients. (en)
http://linked.open...bank/manufacturer	Hospira inc Pioneer pharmaceuticals inc
sameAs	Foscarnet Foscarnet
Title	Foscarnet (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00529/identifier/chebi/127780 http://linked.opendata.cz/resource/drugbank/drug/DB00529/identifier/chemspider/3297 http://linked.opendata.cz/resource/drugbank/drug/DB00529/identifier/drugbank/DB00529 http://linked.opendata.cz/resource/drugbank/drug/DB00529/identifier/kegg-drug/D00579 http://linked.opendata.cz/resource/drugbank/drug/DB00529/identifier/national-drug-code-directory/0186-1906-01 http://linked.opendata.cz/resource/drugbank/drug/DB00529/identifier/pharmgkb/PA449706 http://linked.opendata.cz/resource/drugbank/drug/DB00529/identifier/pubchem-compound/3415 http://linked.opendata.cz/resource/drugbank/drug/DB00529/identifier/pubchem-substance/46507873 http://linked.opendata.cz/resource/drugbank/drug/DB00529/identifier/wikipedia/Foscarnet
http://linked.open...mechanismOfAction	Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases. (en)
http://linked.open...drugbank/packager	AstraZeneca Inc. Hospira Inc. Mutual pharmaceutical co inc
http://linked.open.../drugbank/synonym	Foscarnet (en) Foscarmet (en) Carboxyphosphonic acid (en) Phosphonoformate (en) Phosphonoformic acid (en) Phosphonomethanoic acid (en)
http://linked.open...drugbank/toxicity	Oral, rat LD<sub>50</sub>: >2,000 mg/kg. Signs of overdose include renal impairment. (en)
http://linked.open...nk/proteinBinding	14-17% (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Charles E. McKenna, "Preparation and use of thiophosphonates and thio-analogues of phosphonoformic acid." U.S. Patent US5072032, issued February, 1953. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0026166
foaf:page	http://www.drugs.com/cdi/foscarnet.html http://www.rxlist.com/cgi/generic2/foscarnet.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B3F77-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B3F7D-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3F7C-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3F79-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3F7A-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B3F7B-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B3F75-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B3F8C-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B3F76-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B3F73-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B3F8E-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B3F74-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Foscarnet
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B3F83-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B3F84-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B3F7E-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B3F7F-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B3F81-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B3F80-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B3F82-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Poorly absorbed after oral administration (bioavailability from 12 to 22%). (en)
http://linked.open.../affectedOrganism	Human Herpes Virus (en)
http://linked.open...casRegistryNumber	63585-09-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 2.13 +/- 0.71 mL/min/kg [patients had normal renal function (CrCl > 80 mL/min] * 68 +/- 8 mL/min/kg [CrCl was 50-80 mL/min] * 34 +/- 9 mL/min/kg [CrCl was 25-49 mL/min] * 20 +/- 4 mL/min/kg [CrCl was 10 - 24 mL/min] (en)
http://linked.open...gbank/containedIn	Epogen 4000 unit/ml vial Foscarnet 24 mg/ml infus bttl Epogen 10000 unit/ml vial
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B3F88-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B3F8A-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B3F8B-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3F8D-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B3F87-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B3F86-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B3F89-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B3F78-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B3F85-363D-11E5-9242-09173F13E4C5

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