About: Norepinephrine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description	Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic. [PubChem] (en)
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http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension. (en)
http://linked.open...bank/manufacturer	Corepharma LLC
sameAs	Norepinephrine Norepinephrine
Title	Norepinephrine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/chebi/18357 http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/chemspider/388394 http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/drugbank/DB00368 http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/kegg-compound/C00547 http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/kegg-drug/D00076 http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/national-drug-code-directory/0409-3375-04 http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/pdb/LNR http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/pubchem-compound/439260 http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/pubchem-substance/46506201 http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/pharmgkb/PA450649 http://linked.opendata.cz/resource/drugbank/drug/DB00368/identifier/wikipedia/Norepinephrine
http://linked.open...mechanismOfAction	Norepinephrine functions as a peripheral vasoconstrictor by acting on alpha-adrenergic receptors. It is also an inotropic stimulator of the heart and dilator of coronary arteries as a result of it's activity at the beta-adrenergic receptors. (en)
http://linked.open...drugbank/packager	Bedford Labs Breckenridge Pharmaceuticals Brighton Pharmaceuticals Bryant Ranch Prepack Pfizer Inc. Cardinal Health Cephalon Inc. Comprehensive Consultant Services Inc.
http://linked.open.../drugbank/synonym	Norepinephrine (en) Arterenol (en) L-Norepinephrine (en) L-noradrenaline (en) Noradrenaline (en) (-)-Arterenol (en) (-)-Noradrenaline (en) (-)-Norepinephrine (en) (R)-(-)-Norepinephrine (en) (R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol (en) (R)-Norepinephrine (en) 4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol (en) Norepinefrina (en) Norepinephrinum (en)
http://linked.open...drugbank/toxicity	In high dose and especially when it is combined with other vasopressors, it can lead to limb ischemia and limb death. (en)
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foaf:page	http://www.drugs.com/mtm/norepinephrine.html http://www.rxlist.com/cgi/generic/norepinephrine.htm
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	51-41-2 (en)
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http://linked.open...gbank/containedIn	Levophed 1 mg/ml ampul Lipitor 80 mg tablet Norepinephrine-d5w 4 mg/250 ml Norepinephrine-ns 4 mg/250 ml Levophed 1 mg/ml vial Norepinephrine 1 mg/ml vial
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