About: Palivizumab

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Humanized monoclonal antibody (IgG1k) produced by recombinant DNA technology, directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV). Synagis is a composite of human (95%) and murine (5%) antibody sequences. The human heavy chain sequence was derived from the constant domains of human IgG1 and the variable framework regions of the VH genes Cor (1) and Cess (2). The human lightchain sequence was derived from the constant domain of Ck and the variable framework regions of the VL gene K104 withJk-4. Palivizumab is expressed from a stable murine (mouse) myeloma cell line (NS0). Palivizumab is composed of to heavy chains (50.6 kDa each) and two light chains (27.6 kDa each), contains 1-2% carbohydrate by weight and has a molecular weight of 147.7 kDa +/- 1 kDa (MALDI-TOF) (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B45FD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B45FE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B45FF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4600-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	18-20 days (in adults) (en)
http://linked.open...ugbank/indication	For prophylaxis of respiratory diseases casued by respiratory syncytial virus. (en)
sameAs	Palivizumab Palivizumab
Title	Palivizumab (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00110/identifier/drugbank/DB00110 http://linked.opendata.cz/resource/drugbank/drug/DB00110/identifier/national-drug-code-directory/60574-4114-1 http://linked.opendata.cz/resource/drugbank/drug/DB00110/identifier/pharmgkb/PA164748781 http://linked.opendata.cz/resource/drugbank/drug/DB00110/identifier/wikipedia/Palivizumab
http://linked.open...mechanismOfAction	Palivizumab binds to the fusion glycoprotein of RSV. This prevents its binding and uptake by host cellular receptors. (en)
http://linked.open...drugbank/packager	3M Health Care Advanced Pharmaceutical Services Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2197684
http://linked.open.../drugbank/synonym	Synagis (en) anti-RSV (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/08-18-24
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0288015
foaf:page	http://www.drugs.com/cdi/palivizumab.html http://www.rxlist.com/cgi/generic2/palivizumab.htm
http://linked.open...l/drug/hasATCCode	Palivizumab
http://linked.open...casRegistryNumber	188039-54-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4601-363D-11E5-9242-09173F13E4C5

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