About: Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells.

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About: Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells. Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	This study is based on our previous findings showing that certain amino acids may protect hybridoma cells against starvation-induced apoptosis. In the present work we have screened 44 amino acids and analogs for their capacity of modulating apoptosis in human T-lymphoblastic leukemia cell line MOLT-4 exposed to starvation in a nutrient-poor medium. The panel of tested substances was found to contain not only compounds with antiapoptotic activity (e.g., L-glutamine, L-histidine, glycine, L-proline, and L-2-aminopentanoic acid), but also compounds with proapoptotic activity (e.g., L-phenylalanine, L-tryptophan, L-arginine, and L-2-aminohexanoic acid). The apoptosis-modulating effects were dependent on fine details of the structure of the compounds. A switch from antiapoptotic activity to proapoptotic activity was found between 6-ami-nohexanoic acid and 7-aminoheptanoic acid, as well as between L-2-aminopentanoic acid and L-2-aminohex-anoic acid. D-amino acids tested were without effect. This study is based on our previous findings showing that certain amino acids may protect hybridoma cells against starvation-induced apoptosis. In the present work we have screened 44 amino acids and analogs for their capacity of modulating apoptosis in human T-lymphoblastic leukemia cell line MOLT-4 exposed to starvation in a nutrient-poor medium. The panel of tested substances was found to contain not only compounds with antiapoptotic activity (e.g., L-glutamine, L-histidine, glycine, L-proline, and L-2-aminopentanoic acid), but also compounds with proapoptotic activity (e.g., L-phenylalanine, L-tryptophan, L-arginine, and L-2-aminohexanoic acid). The apoptosis-modulating effects were dependent on fine details of the structure of the compounds. A switch from antiapoptotic activity to proapoptotic activity was found between 6-ami-nohexanoic acid and 7-aminoheptanoic acid, as well as between L-2-aminopentanoic acid and L-2-aminohex-anoic acid. D-amino acids tested were without effect. (en)
Title	Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells. Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells. (en)
skos:prefLabel	Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells. Antiapoptotic and Proapoptotic Action of Various Amino Acids and Analogs in Starving MOLT-4 Cells. (en)
skos:notation	RIV/61389030:_____/02:56023002!RIV/2003/AV0/A56003/N
http://linked.open.../vavai/riv/strany	141;146
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(OC 844.10), Z(AV0Z5038910)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Franěk, František Fismolová, Ivana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	638512
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/02:56023002
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	amino acids; MOLT-4; apoptosis (en)
http://linked.open.../riv/klicoveSlovo	amino acids apoptosis MOLT-4
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[7FF2F47C4710]
http://linked.open...i/riv/nazevZdroje	Archives of Biochemistry and Biophysics
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/OC%20844.10
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	398
http://linked.open...iv/tvurceVysledku	Franěk, František Fismolová, Ivana Eckschlanger, T.
http://linked.open...n/vavai/riv/zamer	Physiological and genetical bases of plant development, cell cycle, morphogenesis, stress reactions and biotechnologies. Genome organisation and function
issn	0003-9861
number of pages	6 (xsd:int)

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