About: Anatomy of Enzyme Channels

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.biomedcentral.com/content/pdf/s12859-014-0379-x.pdf
Description	Background: Enzyme active sites can be connected to the exterior environment by one or more channels passing through the protein. Despite our current knowledge of enzyme structure and function, surprisingly little is known about how often channels are present or about any structural features such channels may have in common. Results: Here, we analyze the long channels (i.e. > 15 angstrom) leading to the active sites of 4,306 enzyme structures. We find that over 64% of enzymes contain two or more long channels, their typical length being 28 angstrom. We show that amino acid compositions of the channel significantly differ both to the composition of the active site, surface and interior of the protein. Conclusions: The majority of enzymes have buried active sites accessible via a network of access channels. Background: Enzyme active sites can be connected to the exterior environment by one or more channels passing through the protein. Despite our current knowledge of enzyme structure and function, surprisingly little is known about how often channels are present or about any structural features such channels may have in common. Results: Here, we analyze the long channels (i.e. > 15 angstrom) leading to the active sites of 4,306 enzyme structures. We find that over 64% of enzymes contain two or more long channels, their typical length being 28 angstrom. We show that amino acid compositions of the channel significantly differ both to the composition of the active site, surface and interior of the protein. Conclusions: The majority of enzymes have buried active sites accessible via a network of access channels. (en)
Title	Anatomy of Enzyme Channels Anatomy of Enzyme Channels (en)
skos:prefLabel	Anatomy of Enzyme Channels Anatomy of Enzyme Channels (en)
skos:notation	RIV/00216224:14310/14:00077325!RIV15-MSM-14310___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED1.1.00/02.0068), P(ED2.1.00/03.0058), P(EE2.3.20.0058), P(GBP208/12/G016), P(GPP303/12/P019), S
http://linked.open...iv/cisloPeriodika	november
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Pravda, Lukáš Koča, Jaroslav Otyepka, Michal Sehnal, David Svobodová Vařeková, Radka Banáš, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	3253
http://linked.open...ai/riv/idVysledku	RIV/00216224:14310/14:00077325
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	CATALYTIC SITE ATLAS; ACTIVE-SITE; ION CHANNELS; BIOMACROMOLECULAR CHANNELS; SUBSTRATE PREFERENCES; CYTOCHROMES P450; LIGAND-BINDING; ACCESS TUNNELS; PROTEIN; RESIDUES (en)
http://linked.open.../riv/klicoveSlovo	PROTEIN ACTIVE-SITE RESIDUES LIGAND-BINDING ACCESS TUNNELS BIOMACROMOLECULAR CHANNELS CATALYTIC SITE ATLAS CYTOCHROMES P450 ION CHANNELS SUBSTRATE PREFERENCES
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[B33E02A99604]
http://linked.open...i/riv/nazevZdroje	BMC Bioinformatics
http://linked.open...in/vavai/riv/obor	CE
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Controlling structure and function of biomolecules at the molecular scale: theory meets experiment Central european institute of technology Regional Centre of Advanced Technologies and Materials Integration of Regional Centre of Advanced Technologies and Materials into International Networks of Nanotechnological and Optical Research. Mechanism of ligand access/egress to/from active site of microsomal drug-metabolising cytochromes P450
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	15
http://linked.open...iv/tvurceVysledku	Koča, Jaroslav Otyepka, Michal Berka, Karel Sehnal, David Svobodová Vařeková, Radka Banáš, Pavel Pravda, Lukáš Roman A, Laskowski
http://linked.open...ain/vavai/riv/wos	000345944500002
issn	1471-2105
number of pages	8 (xsd:int)
http://bibframe.org/vocab/doi	10.1186/s12859-014-0379-x
http://localhost/t...ganizacniJednotka	14310

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