About: Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats

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About: Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Trans-resveratrol (tRES) is a polyphenolic compound present in a variety of plants. TRes elicits many actions in human body which are considered to be protective. Some authors reported tRES influence on the activity of cytochrome P450 (CYP450). It is one of the major enzymatic systems. Many substances including drugs are metabolized by CYP450. Its activity depends on many factors e.g. genotype, age, sex, or xenobiotics. Changes in CYP450 activity can play an important role in drug effectiveness and toxicity, thus knowledge of xenobiotic influence on this enzyme is important for predicting drug interactions. The aim of our study was to evaluate the influence of sex difference and tRES administration on activity of CYP1A2 in rats. Male and female Wistar albino rats were used. Animals weighing 200g were housed under controlled conditions with free access to food and water. Animals were divided into 4 groups. Two groups were males and two females. Trans-resveratrol (tRES) is a polyphenolic compound present in a variety of plants. TRes elicits many actions in human body which are considered to be protective. Some authors reported tRES influence on the activity of cytochrome P450 (CYP450). It is one of the major enzymatic systems. Many substances including drugs are metabolized by CYP450. Its activity depends on many factors e.g. genotype, age, sex, or xenobiotics. Changes in CYP450 activity can play an important role in drug effectiveness and toxicity, thus knowledge of xenobiotic influence on this enzyme is important for predicting drug interactions. The aim of our study was to evaluate the influence of sex difference and tRES administration on activity of CYP1A2 in rats. Male and female Wistar albino rats were used. Animals weighing 200g were housed under controlled conditions with free access to food and water. Animals were divided into 4 groups. Two groups were males and two females. (en)
Title	Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats (en)
skos:prefLabel	Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats (en)
skos:notation	RIV/00216224:14110/08:00024889!RIV10-GA0-14110___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA525/06/1757), Z(MSM0021622404)
http://linked.open...iv/cisloPeriodika	S
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Juřica, Jan Zendulka, Ondřej Zahradníková, Lucia Totušek, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Masarykova univerzita / Lékařská fakulta
http://linked.open...dnocenehoVysledku	400543
http://linked.open...ai/riv/idVysledku	RIV/00216224:14110/08:00024889
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	trans-resveratrol; quercetin; cytochrome P-450 (en)
http://linked.open.../riv/klicoveSlovo	quercetin trans-resveratrol cytochrome P-450
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[F6DEAEA9F63E]
http://linked.open...i/riv/nazevZdroje	Prague Medical Report
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Polyphenolic compounds of grapes, wines and their antimutagenic and antioxidative properties
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	109
http://linked.open...iv/tvurceVysledku	Juřica, Jan Zendulka, Ondřej Zahradníková, Lucia Totušek, Jiří
http://linked.open...n/vavai/riv/zamer	The Internal Organisation and Neurobiological Mechanisms of Functional CNS Systems under Normal and Pathological Conditions
issn	1214-6994
number of pages	2 (xsd:int)
http://localhost/t...ganizacniJednotka	14110
is http://linked.open...avai/riv/vysledek of	Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats Trans-resveratrol enhances sex differences in CYP1A2 metabolic activity in rats

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