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Description
| - Introduction Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. The aim of this study was to determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Materials and Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17,5 months, median age 57 years (39-67), DS stadium: stage I 7,1%, II 24,3%, III 68,6%; A/B - 84.3%/15.7%.
- Introduction Cytogenetic abnormalities in multiple myeloma (MM) are one of the most important independent prognostic factors. Based on cytogenetic findings MM patients (pts.) could be divided into prognostic groups. The aim of this study was to determine the correlation between the aberration of the chromosome 13, rearrangement of IGH gene, translocations t(11;14) and t(4;14), the deletion of 17p13 and the prognostic factors in the patients with newly diagnosed MM who underwent autologous transplantation (AT) according protocol of CMG 2002 trial. Materials and Methods Fluorescence in situ hybridization and cytoplasm immunoglobulin staining (cIg-FISH) were used to detect monotypic plasma cells and aberrations mentioned above. Cytogenetic abnormalities were found in 70 newly diagnosed patients with MM, median of follow-up 17,5 months, median age 57 years (39-67), DS stadium: stage I 7,1%, II 24,3%, III 68,6%; A/B - 84.3%/15.7%. (en)
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Title
| - CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION
- CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION (en)
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skos:prefLabel
| - CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION
- CORRELATION BETWEEN CHROMOSOMAL ABERRATIONS AND STANDARD PROGNOSTIC FACTORS IN PATIENTS WITH MULTIPLE MYELOMA UNDERGOING AUTOLOGOUS STEM CELL TRANSPLANTATION (en)
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skos:notation
| - RIV/00216224:14110/07:00019111!RIV10-MZ0-14110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
| - Pour, Luděk
- Kuglík, Petr
- Krejčí, Marta
- Hájek, Roman
- Adam, Zdeněk
- Filková, Hana
- Oltová, Alexandra
- Křivanová, Andrea
- Grešliková, Henrieta
- Smejkalová, Jana
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14110/07:00019111
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - multiple myeloma; cIg FISH; chromosomal changes; autologous stem cell transplantation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...v/mistoKonaniAkce
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http://linked.open...i/riv/mistoVydani
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Adam, Zdeněk
- Hájek, Roman
- Krejčí, Marta
- Kuglík, Petr
- Pour, Luděk
- Filková, Hana
- Oltová, Alexandra
- Grešliková, Henrieta
- Křivanová, Andrea
- Smejkalová, Jana
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http://linked.open...vavai/riv/typAkce
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http://linked.open.../riv/zahajeniAkce
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issn
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number of pages
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http://purl.org/ne...btex#hasPublisher
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