About: New Molecularly Targeted Therapies for Glioblastoma Multiforme

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/
Description	Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults, exhibiting high mortality. Standard therapy (surgery, radiotherapy and chemotherapy with temozolomide) has only limited effectiveness. The progress in genomics regarding GBM, in the detection of new markers of oncogenesis, abnormalities in signalling pathways, tumor microenvironment, and pathological angiogenesis over the past decade are briefly discussed. The role of novel prognostic in this review biomarkers [isocitrate dehydrogenases 1 and 2, CpG island methylator phenotype, promoter methylation status of the MGMT (O-6-methylguanine-methyltransferase) gene] is also discussed. New targeted therapeutic approaches are classified into several functional subgroups, such as inhibitors of growth factors and their receptors, inhibitors of proteins of intracellular signaling pathways, epigenetic gene-expressing mechanisms, inhibitors of tumor angiogenesis, tumor imunotherapy and vaccines. Finally novel possibilities for GBM treatment are summarized in this review. Glioblastoma multiforme (GBM) is the most malignant brain tumor in adults, exhibiting high mortality. Standard therapy (surgery, radiotherapy and chemotherapy with temozolomide) has only limited effectiveness. The progress in genomics regarding GBM, in the detection of new markers of oncogenesis, abnormalities in signalling pathways, tumor microenvironment, and pathological angiogenesis over the past decade are briefly discussed. The role of novel prognostic in this review biomarkers [isocitrate dehydrogenases 1 and 2, CpG island methylator phenotype, promoter methylation status of the MGMT (O-6-methylguanine-methyltransferase) gene] is also discussed. New targeted therapeutic approaches are classified into several functional subgroups, such as inhibitors of growth factors and their receptors, inhibitors of proteins of intracellular signaling pathways, epigenetic gene-expressing mechanisms, inhibitors of tumor angiogenesis, tumor imunotherapy and vaccines. Finally novel possibilities for GBM treatment are summarized in this review. (en)
Title	New Molecularly Targeted Therapies for Glioblastoma Multiforme New Molecularly Targeted Therapies for Glioblastoma Multiforme (en)
skos:prefLabel	New Molecularly Targeted Therapies for Glioblastoma Multiforme New Molecularly Targeted Therapies for Glioblastoma Multiforme (en)
skos:notation	RIV/00216208:11140/12:10123822!RIV13-MSM-11140___
http://linked.open...avai/predkladatel	Lékařská fakulta v Plzni
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Rohan, Vladimír Topolčan, Ondřej Ferda, Jiří Polívka, Jiří Polívka, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	154064
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/12:10123822
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	review; personalised medicine; tumor biomarkers; molecularly targeted therapeutics; Glioblastoma multiforme (en)
http://linked.open.../riv/klicoveSlovo	Glioblastoma multiforme review molecularly targeted therapeutics personalised medicine tumor biomarkers
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[F3FDA6075285]
http://linked.open...i/riv/nazevZdroje	Anticancer Research
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Ferda, Jiří Polívka, Jiří Rohan, Vladimír Topolčan, Ondřej
http://linked.open...ain/vavai/riv/wos	000306254300064
issn	0250-7005
number of pages	12 (xsd:int)
http://localhost/t...ganizacniJednotka	11140
is http://linked.open...avai/riv/vysledek of	New Molecularly Targeted Therapies for Glioblastoma Multiforme

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