About: Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Neurofilaments are cytoskeletal proteins localized within axons, which may interact with the immune system during and following tissue destruction in multiple sclerosis (MS). Antibodies against the medium neurofilament subunit synthesized intrathecally may reflect axonal damage in MS patients. Both immunoglobulin G (IgG) and M (IgM) responses against the purified native medium subunit of neurofilaments (NFM) using enzyme-linked immunosorbent assay (ELISA) were determined in paired serum and cerebrospinal fluid samples obtained from 49 MS patients, 16 normal controls (CN), 21 control patients with miscellaneous diseases (CD) and 14 patients with neurodegenerative disorders (CDEG). Intrathecal production of IgM and IgG antibodies to NFM were elevated in MS patients compared to the CN or CD groups (p < 0.04 for IgM, p < 0.01 for IgG). The increase was present in all the MS courses (relapsing-remitting, primary and secondary progressive). Similar local anti-NFM IgG and IgM synthesis occurred in the Neurofilaments are cytoskeletal proteins localized within axons, which may interact with the immune system during and following tissue destruction in multiple sclerosis (MS). Antibodies against the medium neurofilament subunit synthesized intrathecally may reflect axonal damage in MS patients. Both immunoglobulin G (IgG) and M (IgM) responses against the purified native medium subunit of neurofilaments (NFM) using enzyme-linked immunosorbent assay (ELISA) were determined in paired serum and cerebrospinal fluid samples obtained from 49 MS patients, 16 normal controls (CN), 21 control patients with miscellaneous diseases (CD) and 14 patients with neurodegenerative disorders (CDEG). Intrathecal production of IgM and IgG antibodies to NFM were elevated in MS patients compared to the CN or CD groups (p < 0.04 for IgM, p < 0.01 for IgG). The increase was present in all the MS courses (relapsing-remitting, primary and secondary progressive). Similar local anti-NFM IgG and IgM synthesis occurred in the (en)
Title	Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis (en)
skos:prefLabel	Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis (en)
skos:notation	RIV/00216208:11120/07:00000313!RIV10-MSM-11120___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ME 492), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Bartoš, Aleš Piťha, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	419897
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/07:00000313
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	multiple sclerosis; neurofilament; antibody; intrathecal synthesis; cerebrospinal fluid (en)
http://linked.open.../riv/klicoveSlovo	multiple sclerosis antibody neurofilament cerebrospinal fluid intrathecal synthesis
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[1F7C6C7AD23A]
http://linked.open...i/riv/nazevZdroje	Journal of Neurology
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20492
http://linked.open...UplatneniVysledku	2007
http://linked.open...v/svazekPeriodika	254
http://linked.open...iv/tvurceVysledku	Bartoš, Aleš Fialová, Lenka Piťha, Jiří Kukal, J. Malbohan, I. Soukupová, J.
http://linked.open...ain/vavai/riv/wos	000244300200003
http://linked.open...n/vavai/riv/zamer	Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0340-5354
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis Elevated intrathecal antibodies against the medium neurofilament subunit in multiple sclerosis

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