About: Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QT0FMS-based metabolomics     Goto   Sponge   NotDistinct   Permalink

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Description
  • Two common chemotherapeutic agents, Ifosfamide and cyclophosphamide, are isomers, bu only ifosfamide is known to cause nephrotoxicity and neurotoxicity. UPLC-ESI-QT0FMS-based metabolomics revealed five novel metabolites. The results suggest that precursors of thiodiglycolic acid, may be responsible for Ifosfamide encephalopathy and nephropathy.
  • Two common chemotherapeutic agents, Ifosfamide and cyclophosphamide, are isomers, bu only ifosfamide is known to cause nephrotoxicity and neurotoxicity. UPLC-ESI-QT0FMS-based metabolomics revealed five novel metabolites. The results suggest that precursors of thiodiglycolic acid, may be responsible for Ifosfamide encephalopathy and nephropathy. (en)
Title
  • Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QT0FMS-based metabolomics
  • Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QT0FMS-based metabolomics (en)
skos:prefLabel
  • Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QT0FMS-based metabolomics
  • Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QT0FMS-based metabolomics (en)
skos:notation
  • RIV/00216208:11110/10:7266!RIV11-MSM-11110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 7
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
  • Idle, Jeffrey R.
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 251327
http://linked.open...ai/riv/idVysledku
  • RIV/00216208:11110/10:7266
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • Ifosfamide; Cyclophosphamide; Metabolomics; Ultra-performance liquid chromatography; Time-of-flight mass spectrometry; Tandem mass spectrometry CHROMATOGRAPHY-PHOTOGRAPHY-DENSITOMETRY; BIOLOGICALLY-ACTIVE METABOLITE; CONTINUOUS-INFUSION; MASS-SPECTROMETRY; METHYLENE-BLUE; PHOSPHORAMIDE MUSTARD; URINARY METABOLITES; MAGNETIC-RESONANCE; CANCER-PATIENTS; IDENTIFICATION (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [E38BDE661F47]
http://linked.open...i/riv/nazevZdroje
  • BIOCHEMICAL PHARMACOLOGY
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 80
http://linked.open...iv/tvurceVysledku
  • Idle, Jeffrey R.
  • Gonzalez, Frank J
  • Hoefer, Constance C
  • Krausz, Kristopher W
  • Li, Fei
  • Patterson, Andrew D
http://linked.open...ain/vavai/riv/wos
  • 000281428800014
issn
  • 0006-2952
number of pages
http://localhost/t...ganizacniJednotka
  • 11110
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